Detailed structure of diamond-type lipid cubic nanoparticles

Journal of the American Chemical Society
Borislav AngelovPatrick Couvreur

Abstract

Supramolecular three-dimensional self-assembly of nonlamellar lipids with fragments of the protein immunoglobulin results in a bicontinuous cubic phase fragmented into nanoparticles with open water channels (cubosomes). The structure of the diamond-type cubic nanoparticles is characterized experimentally by freeze-fracture electron microscopy, and it is mathematically modeled with nodal surfaces emphasizing the fluid-like undulations of the cubosomic interfaces. Based on scaling-up and scaling-down approaches, we present stable and intermediate-kind nanoparticles resulting from the cubosomic growth. Our results reveal the smallest stable diamond-type cubosomic entity that can serve as a building block of more complex nanostructured fluid drug delivery vehicles of therapeutic proteins. The evidence presented for lipid-bilayer undulations in the surface region of the protein/lipid cubosomes could have important consequences for possible applications of these hierarchically organized porous nanoparticles.

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Citations

Jul 14, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Edakkal VenugopalRaffaele Mezzenga
Jan 19, 2016·Drug Discovery Today·Zahra Karami, Mehrdad Hamidi
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Jul 31, 2013·Drug Discovery Today·Angelina AngelovaSylviane Lesieur
Jun 25, 2013·International Journal of Pharmaceutics·Angelina AngelovaSylviane Lesieur
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Mar 23, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Sonal Deshpande, Neetu Singh
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Nov 18, 2015·Nature Communications·Davide DemurtasLaurent Sagalowicz
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Mar 29, 2020·Science China Materials·Congcong CuiLu Han
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Aug 27, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Borislav AngelovPatrick Couvreur
May 29, 2010·The Journal of Physical Chemistry. B·Patrizia AndreozziFrancesco Spinozzi
Jul 13, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Edakkal VenugopalGuruswamy Kumaraswamy
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Nov 15, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Borislav AngelovSylviane Lesieur
Jan 18, 2020·The Journal of Physical Chemistry Letters·Miloš T IvanovićJochen S Hub
Jul 14, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Jijo J VallooranEhud M Landau
Oct 13, 2007·Journal of the American Chemical Society·Borislav AngelovPatrick Couvreur

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