Detailed Urinary Excretion Time Courses of Biomarkers of Exposure to Permethrin and Estimated Exposure in Workers of a Corn Production Farm in Quebec, Canada

The Annals of Occupational Hygiene
Stéphanie FerlandMichèle Bouchard

Abstract

Permethrin is a synthetic pyrethroid insecticide widely used in agriculture. Farm workers are thus regularly exposed during spraying season. To help interpret routine biomonitoring results, a proper knowledge of the time courses of biomarkers of exposure is necessary. The kinetics of biomarkers of exposure to permethrin has recently been documented in volunteers exposed to permethrin under controlled conditions but there is a lack of detailed time profiles following real exposure conditions. This study aimed at obtaining data on the excretion time courses of permethrin metabolites in agricultural workers following typical exposure conditions in the field. Twelve workers exposed to permethrin were recruited from a corn production farm in the Montérégie, Quebec, Canada. They provided all their urine voided over a period of 3 days following the onset of a spraying episode of permethrin or work in a treated area. Three major metabolites of permethrin, trans- and cis- 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-l-carboxylic acid metabolites (trans-DCCA, cis-DCCA), and 3-phenoxybenzoic acid (3-PBA), were analyzed. For the applicator, a progressive rise in excretion values was observed with a single peak being reached 29h following...Continue Reading

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Feb 3, 2016·International Archives of Occupational and Environmental Health·Mylène RatelleMichèle Bouchard
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Aug 31, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Bruce A BuchholzBruce D Hammock

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