Detailed volumetric analysis of the hypothalamus in behavioral variant frontotemporal dementia

Journal of Neurology
Martina BocchettaJonathan D Rohrer

Abstract

Abnormal eating behaviors are frequently reported in behavioral variant frontotemporal dementia (bvFTD). The hypothalamus is the regulatory center for feeding and satiety but its involvement in bvFTD has not been fully clarified, partly due to its difficult identification on MR images. We measured hypothalamic volume in 18 patients with bvFTD (including 9 MAPT and 6 C9orf72 mutation carriers) and 18 cognitively normal controls using a novel optimized multimodal segmentation protocol, combining 3D T1 and T2-weighted 3T MRIs (intrarater intraclass correlation coefficients ≥0.93). The whole hypothalamus was subsequently segmented into five subunits: the anterior (superior and inferior), tuberal (superior and inferior), and posterior regions. The presence of abnormal eating behavior was assessed with the revised version of the Cambridge Behavioural Inventory (CBI-R). The bvFTD group showed a 17% lower hypothalamic volume compared with controls (p < 0.001): mean 783 (standard deviation 113) versus 944 (73) mm(3) (corrected for total intracranial volume). In the hypothalamic subunit analysis, the superior parts of the anterior and tuberal regions and the posterior region were significantly smaller in the bvFTD group compared with con...Continue Reading

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Citations

Mar 16, 2016·NeuroImage. Clinical·Martina BocchettaJonathan D Rohrer
Jun 22, 2016·Neurocase·Marilena AielloRaffaella I Rumiati
Feb 7, 2018·Frontiers in Molecular Neuroscience·Pauline VercruysseLuc Dupuis
Jun 10, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Martin GorgesLuc Dupuis
Jul 21, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Rebekah Ahmed, I Sadaf Farooqi
Dec 26, 2018·Neuropathology and Applied Neurobiology·R ConveryJ D Rohrer
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Feb 24, 2017·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Carolin A M KoriathJonathan D Rohrer
Sep 17, 2020·Scientific Data·Clemens NeudorferAndres M Lozano
Nov 24, 2019·Scientific Reports·K ThomasA V Witte
Jan 15, 2019·NeuroImage. Clinical·Laura Blanco-HinojoAssumpta Caixàs
Aug 28, 2020·NeuroImage·Benjamin BillotJuan Eugenio Iglesias
Nov 8, 2020·Annual Review of Physiology·Jo B Henningsen, Camilla Scheele
Apr 26, 2021·NeuroImage. Clinical·Martina BocchettaUNKNOWN Genetic Frontotemporal dementia Initiative (GENFI)
Aug 31, 2021·Brain Communications·Martina BocchettaJonathan D Rohrer
Jun 3, 2020·Dementia and Geriatric Cognitive Disorders·Titta KorhonenEino Solje
Dec 2, 2021·Journal of Neuroscience Research·Melanie Spindler, Christiane M Thiel

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Software Mentioned

NiftyMIDAS
NiftyReg
R
Matlab
Statistical Parametric Mapping ( SPM )
SPSS
Convert3D
bvFTD

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