Detailing renal hemodynamics and oxygenation in rats by a combined near-infrared spectroscopy and invasive probe approach

Biomedical Optics Express
Dirk GrosenickErdmann Seeliger

Abstract

We hypothesize that combining quantitative near-infrared spectroscopy (NIRS) with established invasive techniques will enable advanced insights into renal hemodynamics and oxygenation in small animal models. We developed a NIRS technique to monitor absolute values of oxygenated and deoxygenated hemoglobin and of oxygen saturation of hemoglobin within the renal cortex of rats. This NIRS technique was combined with invasive methods to simultaneously record renal tissue oxygen tension and perfusion. The results of test procedures including occlusions of the aorta or the renal vein, hyperoxia, hypoxia, and hypercapnia demonstrated that the combined approach, by providing different but complementary information, enables a more comprehensive characterization of renal hemodynamics and oxygenation.

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Citations

Jul 21, 2016·Scientific Reports·Kathleen CantowErdmann Seeliger
Oct 19, 2016·Radiology·Thoralf NiendorfErdmann Seeliger
Dec 27, 2019·Acta Physiologica·Thoralf NiendorfAndreas Pohlmann
Dec 15, 2019·International Journal of Molecular Sciences·Vivien AubertPatrick Hannaert
Jul 28, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kaixuan ZhaoYanqiu Feng
May 15, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Georgia MalakasiotiWesley N Hayes
Nov 4, 2017·Scientific Reports·Kathleen CantowErdmann Seeliger
Dec 3, 2020·PloS One·Stepan MalyJiri Fronek
Apr 21, 2021·Journal of Clinical Monitoring and Computing·Ilonka N de KeijzerThomas W L Scheeren

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