Detectability of residual invasive bladder cancer in delayed 18 F-FDG PET imaging with oral hydration using 500 mL of water and voiding-refilling

Annals of Nuclear Medicine
Akira HigashiyamaYoshifumi Narumi

Abstract

2-Fluorine-18-fluoro-2-deoxy-D-glucose positron emission tomography (18F-FDG PET) imaging is not considered useful for assessing bladder cancer due to the physiological uptake of 18F-FDG in the bladder. Despite reports of the detection of bladder cancer by washing out 18F-FDG from the bladder, such methods are invasive and impractical in the routine practice. The purpose of this study was to evaluate prospectively the utility of oral hydration with 500 mL of water and voiding-refilling, a minimally invasive method that we introduced to enable detection of residual invasive bladder cancer on delayed 18F-FDG PET imaging. From January 2015 to December 2017, 267 consecutive patients with bladder cancer underwent 18F-FDG PET/computed tomography scans. Among these patients, 25 (19 men and 6 women; mean age, 72.0 ± 11.3 years) were newly diagnosed as having muscle-invasive bladder cancer by transurethral resection of bladder tumor and T3b or T4 by magnetic resonance imaging (MRI). All patients were orally hydrated with only 500 mL of water and were then instructed to void frequently for 60 min before early 18F-FDG PET imaging. After the scans, they were instructed to hold their urine for 60 min. Then, delayed imaging was performed. Tw...Continue Reading

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Citations

Mar 24, 2020·Nihon Hoshasen Gijutsu Gakkai zasshi·Toyohiro KatoHiroyuki Tsushima
Jul 24, 2020·Current Opinion in Urology·Sarah M H EinerhandBas W G van Rhijn
Oct 30, 2020·Frontiers in Oncology·Antoine GirardMathieu Rouanne

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