Detectable Neuropsychological Differences in Early Preclinical Alzheimer's Disease: A Meta-Analysis

Neuropsychology Review
S Duke HanDaniel A Nation

Abstract

The development of methods for in vivo detection of cerebral beta amyloid retention and tau accumulation have been increasingly useful in characterizing preclinical Alzheimer's disease (AD). While the association between these biomarkers and eventual AD has been demonstrated among cognitively intact older adults, the link between biomarkers and neurocognitive ability remains unclear. We conducted a meta-analysis to test the hypothesis that cognitively intact older adults would show statistically discernable differences in neuropsychological performance by amyloid status (amyloid negative = A-, amyloid positive = A+). We secondarily hypothesized a third group characterized by either CSF tau pathology or neurodegeneration, in addition to amyloidosis (A+/N+ or Stage 2), would show lower neuropsychology scores than the amyloid positive group (A+/N- or Stage 1) when compared to the amyloid negative group. Pubmed, PsychINFO, and other sources were searched for relevant articles, yielding 775 total sources. After review for inclusion/exclusion criteria, duplicates, and risk of bias, 61 studies were utilized in the final meta-analysis. Results showed A+ was associated with poorer performance in the domains of global cognitive function,...Continue Reading

References

Apr 10, 1992·Science·J A Hardy, G A Higgins
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Nov 13, 2008·Archives of Neurology·Howard Jay AizensteinWilliam E Klunk
Jan 20, 2010·Lancet Neurology·Clifford R JackJohn Q Trojanowski
Aug 10, 2010·Journal of Alzheimer's Disease : JAD·Shizuo Hatashita, Hidetomo Yamasaki
Aug 27, 2010·Brain : a Journal of Neurology·Gaël ChételatUNKNOWN Australian Imaging Biomarkers and Lifestyle Study of Ageing (AIBL) Research Group
Oct 23, 2010·NeuroImage·Hwamee OhWilliam J Jagust
Dec 25, 2010·Annals of Neurology·Jonathan M SchottUNKNOWN Alzheimer's Disease Neuroimaging Initiative Investigators
May 3, 2011·Neuropsychologia·Kerryn E PikeChristopher C Rowe
Feb 4, 2012·Neurology·G ChételatUNKNOWN AIBL Research Group
Mar 21, 2012·Neurobiology of Aging·Hwamee OhWilliam J Jagust
Apr 11, 2012·Journal of Neuropathology and Experimental Neurology·Peter T NelsonThomas G Beach
Jul 13, 2012·Neurology·P Murali DoraiswamyUNKNOWN AV45-A11 Study Group
Sep 4, 2012·Neuropsychologia·Rebecca E AmariglioDorene M Rentz
Oct 20, 2012·PloS One·Dominic HollandUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Mar 12, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Miranka WirthWilliam J Jagust
Mar 13, 2013·Lancet Neurology·Victor L VillemagneUNKNOWN Australian Imaging Biomarkers and Lifestyle (AIBL) Research Group
Mar 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Miranka WirthWilliam J Jagust
Apr 19, 2013·Annals of Neurology·Chester A MathisOscar L Lopez
Jun 28, 2013·Neurology·Susan L StarkJohn C Morris
Sep 10, 2013·Lancet Neurology·Stephanie Jb VosAnne M Fagan
Feb 4, 2014·Neurology·Sylvia VilleneuveWilliam J Jagust
Mar 13, 2014·Alzheimer Disease and Associated Disorders·Kevin DuffJohn M Hoffman
Mar 13, 2014·Molecular Psychiatry·P M DoraiswamyUNKNOWN AV45-A11 Study Group
Apr 11, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Willem HuijbersReisa A Sperling
Apr 23, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jessica B LangbaumEric M Reiman
May 7, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Frank JessenUNKNOWN Subjective Cognitive Decline Initiative (SCD-I) Working Group
Jun 3, 2014·JAMA Neurology·Michael C DonohueUNKNOWN Alzheimer’s Disease Cooperative Study

❮ Previous
Next ❯

Citations

Nov 6, 2017·Journal of Alzheimer's Disease : JAD·Daniel A NationAimée Gaubert
Oct 30, 2018·Journal of Alzheimer's Disease : JAD·Andy MadridReid S Alisch
Feb 2, 2019·Alzheimer's Research & Therapy·Fatemah A SakrUNKNOWN Alzheimer Precision Medicine Initiative (APMI)
Jun 10, 2019·Journal of Alzheimer's Disease : JAD·Anna E BlankenUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Oct 28, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Lindsay R ClarkSterling C Johnson
Jan 23, 2020·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Grant L IversonNoah D Silverberg
Mar 11, 2018·Neurology·Lindsay R ClarkCynthia M Carlsson
Sep 15, 2020·Journal of Alzheimer's Disease : JAD·Yen Ying LimAkinori Nakamura
May 31, 2018·Journal of Alzheimer's Disease : JAD·Kyle SteenlandUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Aug 28, 2019·Brain Sciences·Elena ChipiLucilla Parnetti
Aug 8, 2020·Journal of Geriatric Psychiatry and Neurology·Romel IbarraOrestes V Forlenza
Aug 14, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Kirsty LuSebastian J Crutch
Jun 25, 2019·Frontiers in Aging Neuroscience·Lee RyanCarol A Barnes
May 28, 2019·Journal of Alzheimer's Disease : JAD·Li Dong NiuUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Dec 21, 2019·International Psychogeriatrics·Xin Yu
Feb 18, 2020·Current Alzheimer Research·Lisa GadomskyKristina Endres
Sep 4, 2020·Neurology·Alexandra J WeigandUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Nov 14, 2019·Neurobiology of Aging·Pénélope Sévigny DupontSven Joubert
Dec 1, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Erin E SundermannUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 23, 2021·Journal of the International Neuropsychological Society : JINS·Ellen GroberSusan M Resnick
Mar 23, 2021·Journal of the International Neuropsychological Society : JINS·Vanessa Alviarez-SchulzeUNKNOWN Barcelona Brain Health Initiative group
Jul 17, 2021·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Ryan J DoughertyDane B Cook
Jul 24, 2021·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Fredrik ÖhmanKathryn V Papp
Aug 14, 2019·Dementia and Geriatric Cognitive Disorders·Daniela AndriutaOlivier Godefroy

❮ Previous
Next ❯

Software Mentioned

CMA
Comprehensive Meta - Analysis ( CMA )

Related Concepts

Related Feeds

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.