Detecting and interpreting DNA methylation marks

Current Opinion in Structural Biology
Ren RenXiaodong Cheng

Abstract

The generation, alteration, recognition, and erasure of epigenetic modifications of DNA are fundamental to controlling gene expression in mammals. These covalent DNA modifications include cytosine methylation by AdoMet-dependent methyltransferases and 5-methylcytosine oxidation by Fe(II)-dependent and α-ketoglutarate-dependent dioxygenases. Sequence-specific transcription factors are responsible for interpreting the modification status of specific regions of chromatin. This review focuses on recent developments in characterizing the functional and structural links between the modification status of two DNA bases: 5-methylcytosine and 5-methyluracil (thymine).

Citations

Oct 26, 2018·The Journal of Biological Chemistry·Nicholas O HudsonBethany A Buck-Koehntop
Nov 28, 2018·Epigenetics Insights·Maud de Dieuleveult, Benoit Miotto
Dec 20, 2018·Nucleic Acids Research·Jie YangXiaodong Cheng
Aug 11, 2019·Nature Reviews. Molecular Cell Biology·Maxim V C Greenberg, Deborah Bourc'his
Jul 16, 2019·DNA Repair·Yingqian Zhang, Chuanzheng Zhou
Dec 4, 2020·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Juntaek OhDong Wang
Oct 20, 2019·Journal of Molecular Biology·Amelia J HodgesBethany A Buck-Koehntop
May 19, 2021·Nature Reviews. Cancer·Shuai ZhaoGang Greg Wang

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