Detecting circulating tumor cells in patients with advanced non-small cell lung cancer

Genetics and Molecular Research : GMR
Y H XuX F Pan

Abstract

We explored the expression and clinical significance of circulating tumor cells (CTCs) in patients with advanced non-small cell lung cancer (NSCLC). Sixty-six patients with advanced NSCLC at the Oncology Department of Jinzhou Hospital were selected as an observation group between February and December 2013. Healthy volunteers and 20 benign lung disease patients were taken as a control group. Peripheral blood CTCs in the observation and control groups were detected using the CellSearch(®). CTC detection and analysis system, and the relationship between the expression and clinical effect of CTCs and disease progression was analyzed. Peripheral blood CTCs were observed in 47 of the 66 observation group cases (71.21%), but none were found in the control group (P < 0.05). The CTC-positive rate was independent of NSCLC patients' age, gender, smoking habits, histological features, and degree of differentiation (P > 0.05). The CTC-positive rate correlated with pathological staging (P < 0.05). After two courses of chemotherapy, the number of cases with CTCs ≥3 decreased significantly, compared with pre-chemotherapy cases (P < 0.05), and the disease did not progress in 37 cases (34 cases with <3 CTCs and three cases with ≥3 CTCs). Eight ...Continue Reading

Citations

Jun 24, 2016·Expert Review of Anticancer Therapy·Nicola NormannoAntonio Rossi
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sheefa MirzaRakesh Rawal
Aug 30, 2019·Journal of Translational Medicine·Stephanie N ShishidoPeter Kuhn
Jul 16, 2019·Expert Review of Molecular Diagnostics·Marianna GalloNicola Normanno
Jun 14, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ben-Yuan JiangYi-Long Wu

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