Detecting cortical lesions in multiple sclerosis at 7 T using white matter signal attenuation.

Magnetic Resonance Imaging
Katharine T BluesteinPetra Schmalbrock

Abstract

Cortical lesions have recently been a focus of multiple sclerosis (MS) MR research. In this study, we present a white matter signal attenuating sequence optimized for cortical lesion detection at 7 T. The feasibility of white matter attenuation (WHAT) for cortical lesion detection was determined by scanning eight patients (four relapsing/remitting MS, four secondary progressive MS) at 7 T. WHAT showed excellent gray matter-white matter contrast, and cortical lesions were hyperintense to the surrounding cortical gray matter, The sequence was then optimized for cortical lesion detection by determining the set of sequence parameters that produced the best gray matter-cortical lesion contrast in a 10-min scan. Despite the B1 inhomogeneities common at ultra-high field strengths, WHAT with an adiabatic inversion pulse showed good cortical lesion detection and would be a valuable component of clinical MS imaging protocols.

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Citations

Oct 9, 2012·AJNR. American Journal of Neuroradiology·I D KilsdonkM P Wattjes
Apr 18, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Steven KecskemetiAndrew L Alexander
Mar 13, 2015·NMR in Biomedicine·Siegfried TrattnigStefan Haneder
Jun 4, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Manojkumar SaranathanBrian K Rutt
Nov 26, 2015·IEEE Transactions on Medical Imaging·Kolja ThemTobias Knopp
Jul 3, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Massimo FilippiMaria A Rocca
Jul 3, 2013·Current Opinion in Neurology·Marita DaamsFrederik Barkhof

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