Detecting cryoablation with EIT and the benefit of including ice front imaging data

Physiological Measurement
Jon F Edd, B Rubinsky

Abstract

Imaging has made cryosurgery, the destruction of unwanted tissue through freezing, valuable. Electrical impedance tomography (EIT) has been explored as a method to determine the volume of tissue that is frozen during the procedure. However, studies have shown that tissue near the edge of the frozen zone often survives since in this region it may only be the extra-cellular space that is frozen. This threatens the usefulness of cryosurgery for cancer therapy since inaccurate ablation either allows the cancer to survive or increases the chances of complications. Since low-frequency conductivity of tissue increases due to cell membrane impairment, and ablated tissue implies impaired membranes, EIT has the capability to recover images of tissue viability. Cryosurgery is a technique that can benefit from this: EIT scans before freezing and after thawing can show changes in conductivity and hence viability due to treatment. Assuming unfrozen tissue will survive treatment, we explore the use of differential EIT in combination with intra-operative ice front imaging modes that are currently in clinical practice to recover enhanced-resolution images of cryosurgical treatment efficacy in a set of simulated experiments. We also investigate ...Continue Reading

References

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Feb 16, 2005·The Journal of Urology·Thomas L JangRobert B Nadler
Apr 14, 2005·IEEE Transactions on Bio-medical Engineering·Jon F EddBoris Rubinsky

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Citations

Jul 8, 2008·Physiological Measurement·Jon F EddBoris Rubinsky
Dec 4, 2009·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Adam C Mues, Jaime Landman
Jan 1, 2014·Medical Engineering & Physics·X Zhao, K J Chua
Aug 13, 2011·Medical Engineering & Physics·Yossi MandelBoris Rubinsky
Apr 4, 2009·IEEE Transactions on Bio-medical Engineering·Shlomi Laufer, Boris Rubinsky
Jan 8, 2008·Physiological Measurement·Mohanad Shini, Boris Rubinsky
Jul 22, 2011·Physiological Measurement·Mohanad Ahmad ShiniBoris Rubinsky

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