Detecting gene-environment interactions in genome-wide association data.

Genetic Epidemiology
Corinne D EngelmanW James Gauderman

Abstract

Despite the importance of gene-environment (GxE) interactions in the etiology of common diseases, little work has been done to develop methods for detecting these types of interactions in genome-wide association study data. This was the focus of Genetic Analysis Workshop 16 Group 10 contributions, which introduced a variety of new methods for the detection of GxE interactions in both case-control and family-based data using both cross-sectional and longitudinal study designs. Many of these contributions detected significant GxE interactions. Although these interactions have not yet been confirmed, the results suggest the importance of testing for interactions. Issues of sample size, quantifying the environmental exposure, longitudinal data analysis, family-based analysis, selection of the most powerful analysis method, population stratification, and computational expense with respect to testing GxE interactions are discussed.

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Citations

May 7, 2011·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Fedik RahimovJeffrey C Murray
Mar 8, 2011·Yi chuan = Hereditas·Cheng Quan, Xue-Jun Zhang
Dec 11, 2013·Social Psychiatry and Psychiatric Epidemiology·Rudolf Uher
Nov 2, 2012·Human Genetics·Sabine SiegertMichael Krawczak
Jan 12, 2011·Annual Review of Clinical Psychology·Danielle M Dick
Sep 14, 2014·Social Psychiatry and Psychiatric Epidemiology·Daniel W BelskySalomon Israel
Jul 5, 2012·Human Genetics·Hugues AschardKristel Van Steen
Sep 28, 2013·Current Hypertension Reports·Qi ZhaoJiang He
Mar 8, 2012·Chest·Saeher A F Muzaffar, David C Christiani
Jun 5, 2015·Frontiers in Genetics·Virginie OrgogozoArnaud Martin
Jan 17, 2019·American Journal of Epidemiology·W James GaudermanJuan Pablo Lewinger
Aug 21, 2019·Genetic Epidemiology·Jaehoon AnChristoph Lange
Mar 12, 2017·Current Hypertension Reports·R J WakenD C Rao
Nov 13, 2018·Frontiers in Psychology·Gianluca EspositoJessica L Borelli

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