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Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

bioRxiv

Oct 17, 2017

Yakir A. ReshefAlkes L. Price

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Abstract

Biological interpretation of GWAS data frequently involves analyzing unsigned genomic annotations comprising SNPs involved in a biological process and assessing enrichment for disease signal. However, it is often possible to generate signed annotations quantifying whether each SNP allel...read more

Mentioned in this Paper

Gene Expression
Lupus Vulgaris
TRANK1 gene
Crohn Disease
Transcription Factor Binding
IRF1 protein, human
Evaluation
Simulation
Chromatin
Single Nucleotide Polymorphism
76
98
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  • Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

    bioRxiv

    Oct 17, 2017

    Yakir A. ReshefAlkes L. Price

    DOI: 10.1101/204685

    Abstract

    Biological interpretation of GWAS data frequently involves analyzing unsigned genomic annotations comprising SNPs involved in a biological process and assessing enrichment for disease signal. However, it is often possible to generate signed annotations quantifying whether each SNP allel...read more

    Mentioned in this Paper

    Gene Expression
    Lupus Vulgaris
    TRANK1 gene
    Crohn Disease
    Transcription Factor Binding
    76
    98

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