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Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

bioRxiv

Oct 17, 2017

Yakir ReshefAlkes L Price

Abstract

Biological interpretation of GWAS data frequently involves analyzing unsigned genomic annotations comprising SNPs involved in a biological process and assessing enrichment for disease signal. However, it is often possible to generate signed annotations quantifying whether each SNP allel...read more

Mentioned in this Paper

Genome-Wide Association Study
RNA Polymerase II
Myeloid Cell Differentiation
Genome
DNA-Directed RNA Polymerase
Lupus Vulgaris
IRF1 gene
Gene Expression
Evaluation
Cell Differentiation Process
77
59
Paper Details
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Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

bioRxiv

Oct 17, 2017

Yakir ReshefAlkes L Price

PMID: 990204685

DOI: 10.1101/204685

Abstract

Biological interpretation of GWAS data frequently involves analyzing unsigned genomic annotations comprising SNPs involved in a biological process and assessing enrichment for disease signal. However, it is often possible to generate signed annotations quantifying whether each SNP allel...read more

Mentioned in this Paper

Genome-Wide Association Study
RNA Polymerase II
Myeloid Cell Differentiation
Genome
DNA-Directed RNA Polymerase
Lupus Vulgaris
IRF1 gene
Gene Expression
Evaluation
Cell Differentiation Process
77
59

Similar Papers Found In These Feeds

Interferon Stimulated Genes

Interferon-stimulated gene products take on a number of diverse roles. Collectively, they are highly effective at resisting and controlling pathogens. Discover the latest research on interferon-stimulated genes here.

Chromatin Regulators: Differentiation

Chromatin regulators affect gene expression by influencing the access of proteins such as transcription factors to DNA. Here is the latest research on the role of chromatin regulating proteins on cellular differentiation.

Related Papers

Paper Details
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