Detecting glaucomatous progression using GDx with variable and enhanced corneal compensation using Guided Progression Analysis

The British Journal of Ophthalmology
Dilraj S GrewalDavid S Greenfield

Abstract

To compare detection of glaucoma progression with scanning laser polarimetry using two methods for corneal compensation. Normal, glaucoma suspects and glaucoma patients with 36 months' follow-up meeting the eligibility criteria were prospectively enrolled. All subjects underwent complete eye exam, standard automated perimetry (SAP) and scanning laser polarimetry with variable and enhanced corneal compensation (GDxVCC, GDxECC). SAP progression was determined using the visual-field index (VFI). GDx progression was determined using Guided Progression Analysis software (GDxGPA) and was defined as a repeatable change on two consecutive scans compared with two baseline images using any of three strategies: ≥ 150 contiguous pixels on the image progression map (A), four or more adjacent segments on the Temporal Superior Nasal Inferior Temporal graph (B) or a significant change in slope of the summary parameter chart (C). Kappa statistics and logistic regression were used for the analysis. Thirteen normal, 30 glaucoma suspect and 25 glaucomatous eyes participating in the Advanced Imaging in Glaucoma Study were included. Progression was identified in six eyes (8.8%) using GDxVCC and in eight eyes (11.8%) using GDxECC. SAP progression was...Continue Reading

Citations

Dec 4, 2012·The British Journal of Ophthalmology·Lindsey S FolioJoel S Schuman
Aug 16, 2012·Investigative Ophthalmology & Visual Science·Felipe A MedeirosRobert N Weinreb
Nov 10, 2012·Japanese Journal of Ophthalmology·Makoto Araie
Feb 10, 2012·American Journal of Ophthalmology·Felipe A MedeirosRobert N Weinreb
May 31, 2016·Journal of Current Ophthalmology·Hassan HashemiAkbar Fotouhi
Jun 4, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Eunjoo YooYong Yeon Kim
Dec 20, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Maurice SchallenbergKlaus-Peter Steuhl

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