Detecting Glaucomatous Progression With a Region-of-Interest Approach on Optical Coherence Tomography: A Signal-to-Noise Evaluation

Translational Vision Science & Technology
Zhichao WuDonald C Hood

Abstract

To compare two region-of-interest (ROI) approaches and a global thickness approach for capturing progressive circumpapillary retinal nerve fiber layer (cpRNFL) changes on optical coherence tomography (OCT) imaging. Progressive cpRNFL thickness changes were evaluated in 164 eyes with a clinical diagnosis of glaucoma or suspected glaucoma; all eyes underwent optic disc OCT imaging on two visits at least 1 year apart. Such changes were evaluated with a manual ROI approach (ROIM), which involved manual identification of region(s) of observed or suspected glaucomatous damage. The ROIMwas compared with an automatic ROI approach (ROIA), where regions were automatically identified if the cpRNFL thickness fell below the 1% lower normative limits, and to global cpRNFL thickness. These methods were compared using longitudinal signal-to-noise ratios (SNRs), calculated based upon individualized estimates of measurement variability and age-related changes for each ROI, obtained from 321 glaucoma eyes and 394 healthy eyes, respectively. The average longitudinal SNR of the ROIM, ROIAand global thickness methods were -0.46, -0.39, and -0.30 y-1, respectively. The average longitudinal SNR for the ROIMwas significantly more negative compared with...Continue Reading

Citations

Aug 1, 2019·Brain : a Journal of Neurology·Willemien A de Vries-KnoppertAxel Petzold
Feb 28, 2019·Investigative Ophthalmology & Visual Science·Hongli YangClaude F Burgoyne
Aug 8, 2019·Translational Vision Science & Technology·Zhichao WuRobyn H Guymer
Dec 14, 2018·Pharmaceutical Research·Christopher M AdamsGanesh Prasanna
Nov 6, 2020·Translational Vision Science & Technology·Melvi D EguiaDonald C Hood
Jul 23, 2021·Translational Vision Science & Technology·Christopher BowdLinda M Zangwill

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