Detecting impaired glucose tolerance or type 2 diabetes mellitus by means of an oral glucose tolerance test in HIV-infected patients

HIV Medicine
N GianottiA Castagna

Abstract

As a proactive diagnosis of diabetes mellitus (DM) may prevent the onset of severe complications, we used an oral glucose tolerance test (OGTT) to check for impaired glucose tolerance (IGT) and DM in patients with long-standing HIV infection and long durations of exposure to antiretroviral drugs with normal fasting plasma glucose (FPG) levels. This was a cross-sectional, single-centre study. The homeostatic model assessment for insulin resistance (HOMA-IR) and 2-h post-load glucose levels were used to evaluate patients with known HIV-1 infection since before 1988 and no previous diagnosis of DM for whom data on hepatitis C virus (HCV) and hepatitis B virus (HBV) infection were available. Eighty-four Caucasian patients [67 (80%) male; median age 45.7 years; range 43.8-49.1 years] were able to be evaluated; 65 (77%) were coinfected with HCV, and seven (8%) were coinfected with HBV. Median (interquartile range [IQR]) exposure to antiretrovirals was 12.8 (10.4-16.5) years. Fifteen patients (18%) had a previous AIDS-defining event, 64 (76%) had HIV RNA<50 copies/mL, and the median (IQR) CD4 count was 502 (327-628) cells/μL. The median [IQR] FPG was 81 mg/dL (4.5 mmol/L) [75-87 mg/dL (4.2-4.8 mmol/L)], and the median (IQR) HOMA-IR wa...Continue Reading

References

Jun 1, 1993·British Journal of Obstetrics and Gynaecology·E C NwosuR D Atlay
Apr 11, 1996·The New England Journal of Medicine·J P DesprésP J Lupien
May 3, 2001·The New England Journal of Medicine·J TuomilehtoUNKNOWN Finnish Diabetes Prevention Study Group
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Jul 9, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·T M Wallace, D R Matthews
Aug 3, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Daniel KleinStephen Sidney
Nov 20, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Morris SchambelanUNKNOWN International AIDS Society-USA
Mar 11, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jessica E JustmanKathryn Anastos
Jul 19, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Judith S CurrierSally Hodder
Aug 7, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Shruti H MehtaMark S Sulkowski
Oct 10, 2003·Advances in Cardiology·Daniel VittecoqGilles Chironi
Nov 6, 2003·AIDS·Murielle Mary-KrauseUNKNOWN Clinical Epidemiology Group from the French Hospital Database
Nov 25, 2003·The New England Journal of Medicine·Nina Friis-MøllerUNKNOWN Data Collection on Adverse Events of Anti-HIV Drugs (DAD) Study Group
Apr 22, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrea A HowardEllie E Schoenbaum
Feb 16, 2006·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G F de LarrañagaJ A Benetucci
Apr 27, 2007·The New England Journal of Medicine·UNKNOWN DAD Study GroupJens D Lundgren
Jun 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bruno LedergerberUNKNOWN Swiss HIV Cohort Study
Aug 4, 2007·Antiviral Research·Jorge L Martinez-Cajas, Mark A Wainberg
Feb 13, 2008·Diabetes Care·Stephane De WitUNKNOWN Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study
Jul 19, 2008·The American Journal of Gastroenterology·Jee-Fu HuangWan-Long Chuang
Aug 30, 2008·AIDS·UNKNOWN Strategies for Management of Anti-Retroviral Therapy/INSIGHT, UNKNOWN DAD Study Groups
Jan 6, 2009·Diabetes Care·UNKNOWN American Diabetes Association
Jan 6, 2009·Diabetes Care·UNKNOWN American Diabetes Association
Feb 19, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Katherine Samaras
May 16, 2009·AIDS·Adeel A ButtUNKNOWN Veterans Aging Cohort Study
Jan 29, 2010·Diabetes Care·UNKNOWN American Diabetes Association

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Citations

May 24, 2013·Reviews in Endocrine & Metabolic Disorders·Ovidiu GalescuSvetlana Ten
Mar 1, 2013·Current Diabetes Reports·Sanjay Kalra, Navneet Agrawal
Dec 3, 2011·Endocrine·Absalon D Gutierrez, Ashok Balasubramanyam
Mar 29, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Hamid HassonCaterina Uberti-Foppa
Dec 4, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Chengda ZhangTaisheng Li
May 26, 2020·AIDS Research and Human Retroviruses·Liz SimonPatricia E Molina
Nov 12, 2020·Diabetic Medicine : a Journal of the British Diabetic Association·Harriet DaultreyTom Levett
Feb 18, 2021·The Journal of the Association of Nurses in AIDS Care : JANAC·Allison R WebelJulie A Zuñiga

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