Detecting long non-coding RNA biomarkers in prostate cancer liquid biopsies: Hype or hope?

Non-coding RNA Research
Hetty HelsmoortelJo Vandesompele

Abstract

Prostate cancer is a heterogeneous malignancy, with clinical courses widely differing between indolent and aggressive lethal disease. This heterogeneity calls for a more personalized approach towards diagnosis, prognosis, treatment decision, monitoring and follow-up of patients. In this review, we discuss the possibilities and drawbacks of detecting RNA biomarkers in biological fluids to improve disease-specific survival and quality of life. In particular, we examine literature on long non-coding RNAs in blood and urine of prostate cancer patients. We thereby specifically focus on the need for standard operation procedures on many different levels, analytical validation, clinical validation, and assessment of clinical utility. We argue that thorough multi-step validation of putative biomarkers is necessary for successful translation into clinical prostate cancer care. Our recommendations may also prove useful to biomarker research in other cancers.

Citations

Nov 22, 2018·Genes, Chromosomes & Cancer·Lucía LorenziPieter Mestdagh
Oct 3, 2019·Expert Review of Molecular Diagnostics·Emmy BoerrigterJack A Schalken
Feb 28, 2020·Medicina·Vlad Cristian MunteanuIoan Coman
Jan 27, 2019·Experimental and Therapeutic Medicine·Yonghong ZhangYicheng Luo
Sep 3, 2019·Frontiers in Oncology·Ewelina StelcerWiktoria Maria Suchorska
Mar 28, 2020·Expert Review of Molecular Diagnostics·Wei ZhangYue Yu Bai
Jun 10, 2021·Neoplasia : an International Journal for Oncology Research·Susanne G KiddRolf I Skotheim

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
biopsy
blood collection
xenograft
PCR
electron microscopy
reverse transcription quantitative PCR

Software Mentioned

IonTorrent
Kallisto
LNCipedia
GeneCards
Ensembl

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

BioMed Research International
C G H RönnauJack A Schalken
JAMA : the Journal of the American Medical Association
Patrick M M Bossuyt
European Heart Journal
Nicholas J Wald, Joan K Morris
Hypertension
George D Moutsatsos
© 2022 Meta ULC. All rights reserved