PMID: 7542382Apr 1, 1995Paper

Detecting neural tube defects by amniocentesis between 11 and 15 weeks' gestation

Prenatal Diagnosis
B F Crandall, C Chua

Abstract

Forty-two open neural tube defects (NTDs) were identified in our series of 7440 amniocenteses tested between 11 and 15 weeks of gestation. Using a cut-off of > or = 2.0 MOM, the detection rate for open NTDs was 95 per cent; 100 per cent each for anencephaly and spina bifida; and 78 per cent for encephalocele. Two encephaloceles had AFP levels less than 2.0 MOM and negative AChEs. Thirty-four (81 per cent) of these NTDs were tested between 13 and 15 weeks and 8 (19 per cent) before 13 weeks. There were 0.6 per cent false positives by AFP (excluding serious abnormalities and fetal death) and 0.1 per cent after AChE. The likelihood of an open NTD after an elevated AFP (> or = 2.0 MOM) was 24 and 77 per cent for any serious abnormality. These results, when combined with an earlier study, indicate that amniotic fluid AFP appears to be as sensitive a test for open NTDs between 13 and 15 weeks as between 16 and 20 weeks. Additional experience is necessary to determine this before 13 weeks.

References

May 1, 1986·American Journal of Medical Genetics·B F Crandall, M Matsumoto
Nov 14, 1987·Lancet·B F CrandallF Tennant
Mar 1, 1989·Prenatal Diagnosis·F MullerA Boue
Oct 1, 1986·American Journal of Medical Genetics·J Byrne, D Warburton
Jul 1, 1980·Seminars in Perinatology·J N Macri, R R Weiss

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Citations

Feb 13, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R BeckerM Entezami
May 26, 2005·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Linda A BradleyUNKNOWN ACMG Laboratory Quality Assurance Committee
Jul 1, 1997·British Journal of Obstetrics and Gynaecology·N J SebireK H Nicolaides
Oct 2, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Yana N NepomnyashchayaAlex Zhavoronkov

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