Detecting parathyroid adenoma using technetium-99m tetrofosmin: comparison with P-glycoprotein and multidrug resistance related protein expression--a preliminary report

Nuclear Medicine and Biology
Y C ShiauA Kao

Abstract

The aim of this study was to investigate the relationships among technetium-99m tetrofosmin (Tc-TF) accumulation in parathyroid adenoma and the expression of P-glycoprotein (Pgp) or multidrug resistance related protein (MRP). Before operation, 33 patients with parathyroid adenomas (larger than 1.5 gm) were studied with parathyroid scintigraphy 10 minutes and 2 hours after intravenous injection of Tc-TF before operation. Immunohistochemical analyses (IHA) were performed on multiple nonconsecutive sections of operative parathyroid specimens to detect Pgp or MRP expression. According to the results of IHA, the 33 parathyroid adenomas were separated into four groups: (1) 2 adenomas with both positive Pgp and positive MRP expression, (2) 1 adenomas with positive Pgp but negative MRP expression, (3) 2 adenomas with negative Pgp but positive MRP expression, and (4) 28 adenomas with both negative Pgp and negative MRP expression. All of 28 adenomas in the group 4 could be detected by Tc-TF parathyroid imaging. All of 5 adenomas in the groups 1 to 3 could not be detected by TcTF parathyroid imaging (p < 0.05). Not only the size of parathyroid adenomas, but also significant Pgp or MRP expression limited the sensitivity of Tc-TF parathyroi...Continue Reading

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Citations

May 15, 2010·American Journal of Surgery·Todd W SwansonSam M Wiseman
Jan 16, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elena V BatrakovaAlexander V Kabanov
Jan 28, 2003·Nuclear Medicine Communications·F PonsD Fuster
Mar 9, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Filipa MendesIsabel Santos
Oct 18, 2011·Nuclear Medicine Communications·Kenneth J NicholsChristopher J Palestro

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