Detecting recent positive selection in the human genome from haplotype structure

Pardis C SabetiEric S Lander


The ability to detect recent natural selection in the human population would have profound implications for the study of human history and for medicine. Here, we introduce a framework for detecting the genetic imprint of recent positive selection by analysing long-range haplotypes in human populations. We first identify haplotypes at a locus of interest (core haplotypes). We then assess the age of each core haplotype by the decay of its association to alleles at various distances from the locus, as measured by extended haplotype homozygosity (EHH). Core haplotypes that have unusually high EHH and a high population frequency indicate the presence of a mutation that rose to prominence in the human gene pool faster than expected under neutral evolution. We applied this approach to investigate selection at two genes carrying common variants implicated in resistance to malaria: G6PD and CD40 ligand. At both loci, the core haplotypes carrying the proposed protective mutation stand out and show significant evidence of selection. More generally, the method could be used to scan the entire genome for evidence of recent positive selection.


Jun 20, 1991·Nature·J H McDonald, Martin Kreitman
Apr 1, 1983·Theoretical Population Biology·Richard R Hudson
Aug 7, 1998·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·C Ruwende, A Hill
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·K TangH Köster
Mar 10, 2001·Nature·R SachidanandamInternational SNP Map Working Group
May 11, 2001·Nature·David ReichEric S Lander
May 25, 2002·Science·Stacey GabrielDavid Altshuler
Jul 26, 2002·Genes and Immunity·P SabetiDominic P Kwiatkowski
Dec 1, 1995·Evolution; International Journal of Organic Evolution·Michel Raymond, François Rousset


Jan 18, 2007·Journal of Molecular Evolution·Benjamin T BrownJason A Wilder
Jul 7, 2010·Human Genetics·María M Abad-GrauFuencisla Matesanz
Mar 1, 2012·Human Genetics·George H PerryCharles Lee
Feb 9, 2010·European Child & Adolescent Psychiatry·Johannes HebebrandAnke Hinney
Sep 7, 2006·Genetica·Matthew W Hahn
Oct 30, 2007·Genetica·Nobuyuki InomataToshiyuki Takano-Shimizu
Oct 9, 2008·Molecular Biotechnology·Andrew Collins
Apr 15, 2004·Medical Hypotheses·Eric Lewin Altschuler
Oct 1, 2013·Trends in Ecology & Evolution·Philipp W Messer, Dmitri A Petrov
Mar 23, 2005·Genomics·James KelleyJohn Trowsdale
Jan 12, 2005·The American Psychologist·Richard S Cooper
Aug 22, 2008·European Journal of Human Genetics : EJHG·A W RyanMark Stoneking
Oct 22, 2009·European Journal of Human Genetics : EJHG·Tuuli LappalainenJuha Kere
Feb 10, 2011·European Journal of Human Genetics : EJHG·Zheng CaiAlun Thomas
May 13, 2010·European Journal of Human Genetics : EJHG·Ming ZhongRuzong Fan
Sep 5, 2013·European Journal of Human Genetics : EJHG·Christopher E HeffelfingerMichael P Snyder
Jul 23, 2009·Heredity·Laurent ExcoffierMatthieu Foll
Mar 24, 2011·Heredity·P W Hedrick
Sep 22, 2011·Heredity·Z A Cheviron, R T Brumfield
Oct 15, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Andrew M PrenticeA J Fulford
Feb 28, 2009·Journal of Human Genetics·Daisuke ShichiAkinori Kimura
Mar 4, 2009·Molecular Psychiatry·T L PetryshenPamela Sklar
Oct 29, 2005·Nature·International HapMap Consortium
May 20, 2006·Nature·Simon GregoryE Prigmore
Nov 24, 2006·Nature·Richard RedonMatthew E Hurles
Oct 19, 2007·Nature·International HapMap ConsortiumJohn Stewart
Jan 31, 2012·Nature Genetics·Erik C AndersenLeonid Kruglyak
Oct 24, 2007·Nature Genetics·Patrick SulemKári Stefánsson
May 23, 2012·Nature Genetics·Wen-Yun YangEran Halperin
Feb 5, 2008·Nature Genetics·Luis B BarreiroLluis Quintana-Murci
Aug 30, 2011·Nature Genetics·Jun CaoDetlef Weigel
Aug 30, 2011·Nature Genetics·Paul F O'Reilly, David J Balding
Oct 1, 2003·Nature Genetics·Jennifer A FloydBruce A Hamilton
Jan 18, 2005·Nature Genetics·Hreinn StefanssonKári Stefánsson
May 10, 2005·Nature Genetics·Alec J JeffreysPeter Donnelly
Dec 13, 2006·Nature Genetics·Sarah A TishkoffPanos Deloukas
Sep 5, 2007·Nature Genetics·Donald F Conrad, Matthew E Hurles
Dec 13, 2005·Nature Reviews. Cancer·D J HunterNational Cancer Institute Breast and Prostate Cancer Cohort Consortium
Jun 14, 2005·Nature Reviews. Genetics·Sandra L GilbertBruce T Lahn
Oct 19, 2007·Nature Reviews. Genetics·Rasmus NielsenAndrew G Clark
Sep 8, 2010·Nature Reviews. Genetics·Edith HeardRichard Young
Sep 17, 2011·Nature Reviews. Genetics·Sharon R Browning, Brian L Browning
Aug 14, 2013·Nature Reviews. Genetics·Ana M ValdesTim D Spector
Sep 21, 2013·Nature Reviews. Genetics·Laura B Scheinfeldt, Sarah A Tishkoff
Jan 20, 2005·European Journal of Human Genetics : EJHG·Sapna ChadhaTimothy J Vyse
Oct 28, 2005·European Journal of Human Genetics : EJHG·Fiorenza PompeiPier Franco Pignatti
Aug 9, 2007·European Journal of Human Genetics : EJHG·Sylvain HaneinMarc Jeanpierre
Nov 29, 2007·European Journal of Human Genetics : EJHG·Hélène MagalonEvelyne Heyer
Jul 9, 2003·Genes and Immunity·P A ZimmermanA V S Hill
Jul 30, 2005·Genes and Immunity·G LuoniDominic P Kwiatkowski
Jul 22, 2005·Genes and Immunity·Anna Ramírez-SorianoD Comas
May 3, 2007·Heredity·Kevin R ThorntonPeter Andolfatto
Sep 14, 2006·The Pharmacogenomics Journal·S V VormfeldeJ Brockmöller
Jun 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Bart FerwerdaMihai G Netea
Apr 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Souvik MukherjeePartha P Majumder
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Michael J KovachSusan McCouch
Apr 12, 2012·Proceedings of the National Academy of Sciences of the United States of America·Christopher M JonesCraig S Wilding
Mar 15, 2006·The Journal of Experimental Medicine·Makoto YawataPeter Parham
Aug 30, 2008·The Journal of Infectious Diseases·Sunil Parikh, Philip J Rosenthal
Jul 29, 2010·The Journal of Infectious Diseases·Miriam K LauferChristopher V Plowe
Nov 13, 2009·Carcinogenesis·Charles C ChungS J Chanock
Jun 29, 2010·Epidemiologic Reviews·David Sullivan
Jan 1, 2009·Genome Biology and Evolution·Chun-Hsi ChenFeng-Chi Chen
Sep 29, 2009·Human Molecular Genetics·Fuli YuDavid Reich
May 14, 2010·Human Molecular Genetics·Michael NothnagelMichael Krawczak
Aug 26, 2011·Human Molecular Genetics·Estelle VasseurLluis Quintana-Murci
Sep 25, 2004·The Journal of Heredity·Kenneth K KiddJeffrey M Kidd
Mar 31, 2011·The Journal of Heredity·P Wiener, Ricardo Pong-Wong
Jan 17, 2012·The Journal of Heredity·Jessica L CrisciJeffrey D Jensen
Jan 18, 2008·Molecular Biology and Evolution·J Michael MacphersonDmitri A Petrov
Feb 26, 2008·Molecular Biology and Evolution·Jian LuChung-I Wu
Mar 28, 2008·Molecular Biology and Evolution·Han LiangWen-Hsiung Li
Jun 6, 2008·Molecular Biology and Evolution·Ryosuke KimuraKatsushi Tokunaga
Oct 17, 2008·Molecular Biology and Evolution·Weiwei ZhaiMontgomery Slatkin
Nov 8, 2008·Molecular Biology and Evolution·Michael DeGiorgio, Noah A Rosenberg
Dec 19, 2008·Molecular Biology and Evolution·Sridhar KudaravalliJonathan K Pritchard
Mar 13, 2009·Molecular Biology and Evolution·Laura B ScheinfeldtJoshua M Akey
Jun 3, 2009·Molecular Biology and Evolution·Anna Ferrer-AdmetllaFerran Casals
Jul 7, 2009·Molecular Biology and Evolution·Andrés Moreno-EstradaElena Bosch
Aug 5, 2009·Molecular Biology and Evolution·Miroslava OgorelkovaXavier Estivill
Sep 12, 2009·Molecular Biology and Evolution·Daniel GarriganJohn Wakeley
May 7, 2010·Molecular Biology and Evolution·Punita Juneja, Brian P Lazzaro
Oct 13, 2010·Molecular Biology and Evolution·Jun OhashiNaoyuki Tsuchiya
Oct 22, 2010·Molecular Biology and Evolution·Shuhua XuLi Jin
Oct 11, 2011·Molecular Biology and Evolution·Alexander GusevItsik Pe'er
Aug 13, 2011·Molecular Biology and Evolution·Irene Gallego RomeroToomas Kivisild
Feb 10, 2012·Molecular Biology and Evolution·Shigeki NakagomeHiroki Oota
Jun 13, 2012·Molecular Biology and Evolution·Alfred Amambua-NgwaStephen F Schaffner
Jan 8, 2013·Molecular Biology and Evolution·Zélia FerreiraBelen Hurle
May 11, 2013·Molecular Biology and Evolution·Yan LiYa-Ping Zhang
Aug 10, 2013·Molecular Biology and Evolution·Martina BradicRichard L Borowsky
Feb 2, 2012·Mutagenesis·Stefanie HuhnAsta Försti
Dec 1, 2006·Nucleic Acids Research·Jungsun ParkDoheon Lee
Oct 27, 2007·Nucleic Acids Research·Gabrielle C NickelMark D Adams
Dec 14, 2005·Pharmacogenetics and Genomics·M SchirmerL Wojnowski
Feb 28, 2008·Pharmacogenetics and Genomics·Keyue Ding, Iftikhar J Kullo
Feb 14, 2009·Pharmacogenetics and Genomics·M SchirmerJ Brockmöller
May 10, 2012·Pharmacogenetics and Genomics·Matthew J BinningtonRachel F Tyndale
Feb 16, 2010·Current Opinion in Lipidology·Laurence D ParnellChao-Qiang Lai
Jul 19, 2005·Proceedings. Biological Sciences·Denae NashTim Jc Anderson
Jul 2, 2010·Proceedings. Biological Sciences·Daniel R Schrider, Matthew W Hahn
Sep 3, 2011·Proceedings. Biological Sciences·P Wiener, Samantha Wilkinson
Dec 17, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Taras K OleksykStephen J O'Brien
Nov 17, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Kees van Oers, Jakob C Mueller
Dec 28, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Paul A HohenloheWilliam A Cresko
Feb 9, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Kristian G AndersenPardis C Sabeti
Jan 14, 2010·Genome Research·John E PoolRasmus Nielsen
Mar 7, 2009·Genome Research·Brian P McEvoyPeter M Visscher
Mar 25, 2009·Genome Research·Joseph K PickrellJonathan K Pritchard
Mar 13, 2009·Genome Research·Rasmus NielsenAndrew G Clark
Jan 21, 2010·Genome Research·Hua ChenDavid Reich
Oct 28, 2010·Genome Research·Chia Lin ChangSheau Yu Teddy Hsu
Jun 6, 2012·Genome Research·Joel T DudleySudhir Kumar
Oct 4, 2003·Genome Research·Sun Shim Choi, Bruce T Lahn
Jan 6, 2005·Genome Research·Analabha BasuPartha P Majumder
Sep 6, 2005·Genome Research·Ines HellmannSusan E Ptak
Oct 28, 2005·Genome Research·Stephen F SchaffnerDavid Altshuler
Oct 28, 2005·Genome Research·Rasmus NielsenCarlos D Bustamante
Oct 28, 2005·Genome Research·Christopher S CarlsonDeborah A Nickerson
Dec 13, 2005·Genome Research·John P PollingerRobert K Wayne
Jul 11, 2006·Genome Research·Joanna L KelleyJoshua M Akey
Sep 4, 2003·Genome Research·John D H SteadAlec J Jeffreys
Sep 2, 2004·Cold Spring Harbor Symposia on Quantitative Biology·Jaume BertranpetitA Navarro
Apr 24, 2010·Cold Spring Harbor Symposia on Quantitative Biology·C R Linnen, Hopi E Hoekstra
Jun 9, 2007·Annals of Human Genetics·Dimitar N AzmanovJuleen A Cavanaugh
Jan 12, 2010·Annals of Human Genetics·Georgios AthanasiadisPedro Moral
Jun 12, 2012·Annals of Human Genetics·Magdalena Gayà-VidalPedro Moral
May 23, 2012·Annals of Human Genetics·Santiago RodriguezIan N M Day
Oct 20, 2007·Biological Reviews of the Cambridge Philosophical Society·Anthony LevasseurPierre Pontarotti
Feb 7, 2009·Science·Tovi M AndersonGregory S Barsh
Oct 8, 2011·Science·A Fournier-LevelA M Wilczek
Apr 16, 2009·Clinical Microbiology Reviews·Jenefer M BlackwellDavid Burgner
Nov 19, 2013·Genome Génome / Conseil National De Recherches Canada·Duc LuStephen P Miller
Nov 28, 2013·Annual Review of Genetics·Joseph J VittiPardis C Sabeti
Jul 10, 2013·Annual Review of Genomics and Human Genetics·Wenqing Fu, Joshua M Akey
Apr 28, 2010·Annual Review of Nutrition·Francesca LucaAnna Di Rienzo
Jan 1, 2008·Annual Review of Anthropology·Angela M Hancock, Anna Di Rienzo
Oct 7, 2003·Annual Review of Genomics and Human Genetics·Sarah A Tishkoff, Brian C Verrelli
Jul 3, 2008·Annual Review of Genomics and Human Genetics·Michael C Campbell, Sarah A Tishkoff
May 29, 2008·Annual Review of Genomics and Human Genetics·Joanna L Kelley, Willie J Swanson
Apr 20, 2005·Human Heredity·Goncalo R AbecasisThomas E Nichols
Nov 2, 2006·Human Heredity·Hui WangInternational Collaborative Group on Isolated Populations
Jul 23, 2013·Investigative Ophthalmology & Visual Science·Mark ChristopherMichael D Abràmoff
May 3, 2008·The Journal of Clinical Investigation·Teri A ManolioFrancis S Collins
Sep 2, 2011·The Journal of Clinical Investigation·David J Friedman, Martin R Pollak
Mar 17, 2009·Genetics, Selection, Evolution : GSE·Joseph Lachance
Jan 30, 2010·BMC Bioinformatics·Julie HussinDamian Labuda
Sep 14, 2006·BMC Bioinformatics·Stephan HutterJulio Rozas
Sep 3, 2010·BMC Evolutionary Biology·Matteo FumagalliManuela Sironi
Sep 3, 2010·BMC Evolutionary Biology·Andrés Moreno-EstradaElena Bosch
Jun 22, 2011·BMC Evolutionary Biology·Yann C KlimentidisSadeep Shrestha
Mar 10, 2011·BMC Evolutionary Biology·Zehong DingSibin Yu
Jul 11, 2013·BMC Evolutionary Biology·Most Mauluda AkhtarAntonella Monticelli
Apr 18, 2008·BMC Evolutionary Biology·Edward Hollox, John A L Armour
Mar 4, 2008·BMC Evolutionary Biology·Santos AlonsoConcepción de la Rúa
Sep 8, 2009·BMC Evolutionary Biology·Feng ChengChangqing Zeng
Sep 24, 2013·BMC Genetics·Srilakshmi RajWilliam Amos
Jan 7, 2010·BMC Genomics·Chad D HuffAlan R Rogers
Mar 24, 2012·BMC Genomics·Tamara HoferLaurent Excoffier
Sep 21, 2011·Malaria Journal·Adel DrissJonathan K Stiles
Mar 1, 2012·Journal of Translational Medicine·Erin E BaschalJanet C Siebert
Dec 14, 2004·Human Genomics·Rasmus Nielsen
Jul 12, 2005·Human Genomics·James Ronald, Joshua M Akey
Aug 7, 2008·Genome Biology·Philipp KhaitovichSabine Bahn
Nov 3, 2010·Genome Biology·Amy L WilliamsDavid K Gifford
Jan 1, 2010·Genes & Genetic Systems·Yoshiyuki Suzuki
Oct 24, 2008·PLoS Biology·Josefa GonzálezDmitri A Petrov
Oct 6, 2005·PLoS Genetics·Fuli YuRichard A Gibbs
Oct 29, 2005·PLoS Genetics·Gil McVeanR Chaix
May 10, 2006·PLoS Genetics·Deborah Charlesworth
Dec 19, 2006·PLoS Genetics·Pleuni S Pennings, Joachim Hermisson
Apr 24, 2007·PLoS Genetics·Jeffrey M KiddEvan E Eichler
Jun 5, 2007·PLoS Genetics·Scott H WilliamsonRasmus Nielsen
Nov 1, 2008·PLoS Genetics·Shalini NairTim Jc Anderson
Jan 17, 2009·PLoS Genetics·James J CaiDmitri A Petrov
Jun 9, 2009·PLoS Genetics·Graham CoopJonathan K Pritchard
Dec 17, 2009·PLoS Genetics·Jasmin Coulombe-HuntingtonJacek Majewski
May 27, 2010·PLoS Genetics·Sol KatzmanDavid Haussler
Dec 24, 2011·PLoS Genetics·Nicholas A JohnsonHua Tang
Jun 12, 2013·PLoS Genetics·Kelley Harris, Rasmus Nielsen
Mar 4, 2014·PLoS Genetics·Saber QanbariH Simianer
Feb 28, 2008·PloS One·David A HughesMark Stoneking
Sep 6, 2008·PloS One·Francesca LucaAndrea Novelletto
Nov 20, 2008·PloS One·Tong ZhouClaus O Wilke
Aug 11, 2011·PloS One·Sergio CocozzaAntonella Monticelli
Oct 3, 2012·PloS One·Kshitij WaghGyan Bhanot
Jan 26, 2013·PloS One·Wei QianShuhua Xu
Apr 5, 2013·PloS One·Dunfei PanJian-Feng Liu
Dec 19, 2013·PloS One·Evan KochMark Kirkpatrick
Apr 18, 2014·PloS One·Yunlong MaXiangdong Ding
Feb 28, 2003·Pharmacogenomics·Hongyu ZhaoMitchell H Gail
Jul 29, 2004·Genetics·Yuseob Kim, Rasmus Nielsen
Jul 16, 2005·Genetics·Matthew A SaundersMichael W Nachman
Mar 21, 2006·Genetics·Kenneth M OlsenMichael D Purugganan
Jun 6, 2006·Genetics·Cristina O Micali, Myron L Smith
Dec 22, 2006·Genetics·P PfaffelhuberA Wakolbinger
Feb 5, 2008·Genetics·Joanna L Kelley, Willie J Swanson
May 22, 2008·Genetics·P PfaffelhuberWolfgang Stephan
Aug 12, 2008·Genetics·Noah A Rosenberg, Mattias Jakobsson
Aug 12, 2008·Genetics·Gabrielle C NickelMark D Adams
Aug 22, 2008·Genetics·Daniel Zivković, Thomas Wiehe
Nov 26, 2009·Genetics·B Charlesworth, Deborah Charlesworth
Jul 2, 2010·Genetics·Anders AlbrechtsenRasmus Nielsen
Jul 9, 2010·Genetics·Luca FerrettiS E Ramos-Onsins
Jan 8, 2011·Genetics·Zach Gompert, C A Buerkle
Aug 16, 2011·Genetics·Olivier C Martin, Frédéric Hospital
Apr 12, 2012·Genetics·Philipp W Messer, Richard A Neher
Jun 21, 2012·Genetics·Graham Coop, Peter Ralph
Jun 21, 2012·Genetics·P PavlidisWolfgang Stephan
Sep 11, 2012·Genetics·Julie M GrankaMarcus W Feldman
Nov 15, 2012·Genetics·Nafisa-Katrin Seich Al BasatenaPaul F O'Reilly
May 6, 2004·Genetics·Anthony C Allison
Aug 4, 2004·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·John W Belmont, Richard A Gibbs
Jul 13, 2011·International Journal of Molecular Sciences·Heather Kirk, Joanna R Freeland
Oct 13, 2009·Yi chuan = Hereditas·Kao Lin, Haipeng Li
Oct 27, 2012·Yi chuan = Hereditas·Yunlong MaXiangdong Ding
Oct 27, 2012·Yi chuan = Hereditas·Xiuling LiBin Fan
Feb 15, 2012·Advances in Nutrition·Kaixiong Ye, Zhenglong Gu
Aug 19, 2007·Journal of Postgraduate Medicine·V Tripathy, B M Reddy
Mar 27, 2007·International Journal of Biological Sciences·Kefei ChenLawrence B Schook
Jun 3, 2014·Nature Communications·Arthur KoPäivi Pajukanta
Mar 31, 2010·Personalized Medicine·Tesfaye M BayeMichael Olivier
Apr 21, 2006·PLoS Biology·Christopher ToomajianMagnus Nordborg
Feb 9, 2006·PLoS Biology·Xiaoxia WangJianzhi Zhang
Dec 23, 2010·Pharmacogenomics·Tim Jc AndersonDavid Fidock
Feb 24, 2006·PLoS Biology·Benjamin F VoightJonathan K Pritchard
Mar 4, 2014·Autoimmune Diseases·Paula S RamosCarl D Langefeld
Mar 10, 2006·PLoS Biology·Catriona MacCallum, Emma Hill
Oct 27, 2005·PLoS Biology·Pardis C SabetiEric S Lander
Apr 21, 2009·Pharmacogenomics·Grace S Y PangCaroline G L Lee
Dec 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Eric T WangR K Moyzis
Jun 3, 2014·BMC Genetics·Agnès E SjöstrandMattias Jakobsson
Feb 26, 2014·Current Opinion in Gastroenterology·Eva K K HenriksenTom H Karlsen
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Gurinder Singh AtwalRonit Yarden
Nov 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Uwe StolzJeffrey L Feder
Apr 3, 2014·BMC Evolutionary Biology·Ramatoulie E JanhaRobert T Walton
Feb 5, 2014·Developmental and Comparative Immunology·Remi L Gratacap, Robert T Wheeler
May 29, 2014·EURASIP Journal on Bioinformatics & Systems Biology·Alexandros IliadisXiaodong Wang
Aug 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·W TapperN E Morton
Dec 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hong YangWing Hung Wong
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Matthew A SaundersWen-Hsiung Li
Jun 15, 2014·Journal of Physiological Anthropology·Yoshiki Yasukochi, Yoko Satta
Oct 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Bart FerwerdaMihai G Netea
Apr 9, 2014·Molecular Biology and Evolution·Patrick C BrunnerBruce A McDonald
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Bernard GrisartMichel Georges
May 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kelly PalaisaAntoni Rafalski
Feb 26, 2014·Journal of Applied Genetics·Artur GurgulMonika Bugno-Poniewierska
Feb 21, 2014·Molecular Biology and Evolution·Anna Ferrer-AdmetllaRasmus Nielsen
Sep 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Toshiyuki Takano-ShimizuMasanobu Itoh
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Todd LenczAnil K Malhotra
Nov 12, 2013·The Journal of Heredity·Annette M McCoyMolly E McCue
Apr 4, 2014·Molecular Biology and Evolution·Maud FagnyGuillaume Laval
Mar 7, 2014·Genetics, Selection, Evolution : GSE·Ana M Pérez O'BrienJohann Sölkner
Jan 2, 2007·Proceedings of the National Academy of Sciences of the United States of America·Vincent ButtyDiane Mathis
Sep 10, 2014·International Journal of Evolutionary Biology·Gerald Mboowa
Feb 22, 2012·Human Genetics·Philip GorwoodMichel Simonneau
May 9, 2014·Proceedings of the National Academy of Sciences of the United States of America·Russell ThomsonJayne Raper
Jul 13, 2014·Molecular Biology and Evolution·Zachary A Szpiech, Ryan D Hernandez
Mar 13, 2014·Journal of Applied Genetics·Huizhong FanHuijiang Gao
May 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Alexandre KuhnWilliam F Burkholder
Jun 23, 2010·Annual Review of Genomics and Human Genetics·Masatoshi NeiMasafumi Nozawa
Jan 12, 2011·Annual Review of Immunology·Valérie AbadieBana Jabri
Jan 12, 2011·Annual Review of Immunology·Jean-Laurent CasanovaLluis Quintana-Murci
Dec 20, 2005·Human Genetics·Emily C WalshDavid Altshuler
Jul 6, 2014·Current Opinion in Immunology·Valentina D Mangano, David Modiano
Jul 31, 2014·Heredity·S E Ramos-OnsinsM Amills
Sep 25, 2014·Molecular Biology and Evolution·Feng-Hua LvPaolo Ajmone Marsan
Nov 18, 2014·Human Biology·Aaron J Sams, John Hawks
Aug 31, 2014·Molecular Biology and Evolution·Fernando RacimoMontgomery Slatkin
Jul 18, 2014·Animal : an International Journal of Animal Bioscience·C T MeiraM D S da Mota
Jul 9, 2004·Journal of Genetics·Abdellatif MaalejHammadi Ayadi
Dec 13, 2005·Genes and Immunity·Neil A HanchardDominic P Kwiatkowski
May 20, 2011·Genes and Immunity·R KosoyMichael F Seldin
Aug 13, 2011·Genes and Immunity·J BerghoutP Gros
Nov 26, 2003·Current Opinion in Genetics & Development·Willie J Swanson
Nov 26, 2003·Current Opinion in Genetics & Development·Sarah A Tishkoff, Brian C Verrelli
Jul 31, 2008·Journal of Neural Transmission·Junko SatoToru Nishikawa
Jul 16, 2013·Journal of Statistical Physics·Feng Fu, Martin A Nowaks
Jul 17, 2012·Acta Diabetologica·Issei Yoshiuchi
Jan 9, 2016·Molecular Biology and Evolution·Zhaohui YangBing Su
Nov 29, 2015·Molecular Biology and Evolution·Ian H CheesemanTim Jc Anderson
Feb 10, 2016·Animal Genetics·M FrischknechtM Neuditschko
Feb 13, 2016·Frontiers in Psychology·Martin Fieder, Susanne Huber
Nov 7, 2013·Nucleic Acids Research·Mulin Jun LiJunwen Wang
Sep 10, 2014·BMC Medical Genetics·Shivang S ShahThomas N Williams
Feb 25, 2015·Genomics·Shuhao Qiu, Alexei Fedorov
Oct 1, 2015·Molecular Biology and Evolution·Patrícia Isabel MarquesSusana Seixas
Oct 10, 2012·Trends in Parasitology·Ric N PriceQin Cheng
May 21, 2015·Kidney International·Sophie LimouCheryl A Winkler
Dec 4, 2012·The HUGO Journal·Bryony Leigh Jones, Dallas M Swallow
Apr 10, 2012·Trends in Genetics : TIG·Rebecca C IskowCharles Lee
Mar 27, 2012·Trends in Genetics : TIG·Chiea Chuen Khor, Martin L Hibberd
Aug 21, 2015·Molecular Ecology·Christian D HuberRasmus Nielsen
Sep 1, 2015·Molecular Ecology·Alexandra I VatsiouOscar E Gaggiotti
Nov 22, 2015·Molecular Ecology·Florencia SchlampPhilipp W Messer
Apr 23, 2010·Medical Hypotheses·R Khan, B S Razib Khan
May 22, 2010·Trends in Ecology & Evolution·Katalin CsilléryOlivier François
Mar 1, 2016·American Journal of Human Genetics·Kevin J GalinskyAlkes L Price
Jul 28, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·T S MacFieN I Mundy
May 12, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Erin E BaschalType 1 Diabetes Genetics Consortium
Apr 21, 2009·Trends in Microbiology·B Jesse ShapiroEric J Alm
Nov 25, 2011·The Journal of Investigative Dermatology·Jonathan L Rees, Rosalind M Harding
Nov 8, 2015·Molecular Biology and Evolution·Shigeki NakagomeAnna Di Rienzo
Feb 26, 2011·International Journal of Evolutionary Biology·Hong Shi, Bing Su
May 1, 2007·Current Opinion in Genetics & Development·Michael F Seldin
Apr 28, 2007·Human Immunology·Silvana BonfigliMaurizio Longinotti
Feb 6, 2007·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Michael E SteiperJulia M Zichello
Nov 28, 2015·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·Artur GurgulMonika Bugno-Poniewierska
Oct 24, 2006·Current Opinion in Genetics & Development·Floyd A Reed, Sarah A Tishkoff
Nov 28, 2015·Genetics, Selection, Evolution : GSE·Sithembile O MakinaAzwihangwisi Maiwashe
May 7, 2016·Bioinformatics·Paul R Staab, Dirk Metzler
Sep 17, 2015·Scientific Reports·Jun Hong XiaGen Hua Yue
Sep 16, 2004·Genetic Epidemiology·Andrew G Clark
Sep 16, 2004·Genetic Epidemiology·Tianhua Niu
Aug 17, 2005·Molecular Ecology·Staffan Bensch, Mikael Akesson
Apr 27, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ruth SpinksRobert A Philibert
May 22, 2009·Animal Genetics·P Wiener, B Gutiérrez-Gil
Aug 14, 2003·Genetic Epidemiology·Andrew MorrisKaren Ayres
Nov 15, 2006·American Journal of Physical Anthropology·Eugene E Harris, Diogo Meyer
Nov 16, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·William C SpeedKenneth K Kidd
Feb 5, 2008·Animal Genetics·B J HayesT H E Meuwissen
Oct 25, 2007·Journal of Evolutionary Biology·E G Leigh
Feb 1, 2009·Evolutionary Applications·Evelyne Heyer, Lluis Quintana-Murci
Feb 18, 2016·Molecular Biology and Evolution·John P DidionFernando Pardo-Manuel de Villena
Jun 5, 2007·Evolution; International Journal of Organic Evolution·Dario BeraldiJosephine M Pemberton
Jun 17, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Noa CarreraJavier Costas
Dec 22, 2005·Molecular Ecology·Staffan BenschSusanne Akesson
Jul 17, 2008·Molecular Ecology·P PavlidisWolfgang Stephan
Mar 8, 2011·Molecular Ecology·C A BuerkleT L Parchman
Jun 30, 2010·Molecular Ecology·Carrie S ThurberAna L Caicedo
Jan 9, 2010·Animal Genetics·Saber QanbariH Simianer
Jul 10, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Joseph Lachance, Sarah A Tishkoff
Aug 13, 2010·Molecular Ecology·Amy Lawton-Rauh, Nilda Burgos
May 20, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Fuquan ZhangPozi Liu
Jun 22, 2013·Evolutionary Applications·Estelle Vasseur, Lluis Quintana-Murci
Jun 10, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Rungnapa IttiwutJoel Gelernter
Aug 11, 2010·The New Phytologist·Mathieu SiolSpencer C H Barrett
Sep 17, 2013·Evolution; International Journal of Organic Evolution·Pierre-Alexandre GagnaireLouis Bernatchez
Jun 30, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·K DietrichP Kovacs
May 14, 2011·Molecular Ecology Resources·Wolfgang Stephan
Jun 22, 2011·Molecular Ecology·Mathieu Gautier, Michel Naves
Mar 28, 2013·Ecology and Evolution·Zach GompertMatthew L Forister
Nov 30, 2011·Molecular Ecology·R LaurentR Chaix
Dec 8, 2011·Genetic Epidemiology·F Anthony San LucasPaul Scheet
Jan 26, 2010·Animal Genetics·Saber QanbariH Simianer
Apr 18, 2012·Genetic Epidemiology·Wagner C S MagalhãesEduardo Tarazona-Santos
Dec 24, 2010·Annals of the New York Academy of Sciences·Lluis Quintana-Murci, Luis B Barreiro
Oct 3, 2012·Evolution; International Journal of Organic Evolution·Vera S DominguesHopi E Hoekstra
May 27, 2010·Evolution; International Journal of Organic Evolution·Jay F Storz, Christopher W Wheat
Apr 1, 2015·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·K E KemperM E Goddard
Dec 5, 2013·Evolution; International Journal of Organic Evolution·Matthew R JonesStéphanie Manel
Jan 30, 2015·Evolutionary Anthropology·George H Perry
Jan 1, 2014·American Journal of Physical Anthropology·Milena R ShattuckRipan S Malhi
Aug 19, 2007·American Journal of Human Genetics·Hua TangNeil J Risch
Aug 8, 2015·Molecular Biology and Evolution·Colin A MacleanJames G D Prendergast
Mar 15, 2006·American Journal of Human Genetics·Yali XueChris Tyler-Smith
Apr 13, 2004·American Journal of Human Genetics·E WangR K Moyzis
Apr 17, 2004·American Journal of Human Genetics·C J HoggartPaul M McKeigue
Dec 31, 2005·American Journal of Human Genetics·Neil A HanchardDominic P Kwiatkowski
Oct 7, 2004·Theoretical Population Biology·Graham Coop, Robert C Griffiths
Jun 29, 2004·Trends in Genetics : TIG·Martin Kreitman, Anna Di Rienzo
Jan 18, 2006·American Journal of Human Genetics·Etienne PatinLluis Quintana-Murci
Feb 9, 2006·American Journal of Human Genetics·Jonathan MarchiniInternational HapMap Consortium
Jun 30, 2004·Blood Cells, Molecules & Diseases·Anthi DrousiotouSarah A Tishkoff
Jun 22, 2010·American Journal of Human Genetics·Alexandra ZhernakovaCisca Wijmenga
Sep 25, 2015·Canine Genetics and Epidemiology·Elizabeth R ArnottClaire M Wade
Aug 1, 2015·Journal of Human Genetics·Paula S RamosCarl D Langefeld
May 7, 2015·Molecular Ecology·Anna Fijarczyk, Wiesław Babik
Oct 7, 2006·Seminars in Immunology·Susana CampinoAlain Dessein
Sep 30, 2006·The Lancet Infectious Diseases·David BurgnerJenefer M Blackwell
Aug 1, 2006·Trends in Microbiology·Olivier NeyrollesLluis Quintana-Murci
Jul 1, 2006·Trends in Genetics : TIG·Shameek Biswas, Joshua M Akey
Oct 26, 2005·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Henry Harpending, Gregory Cochran
May 16, 2006·Autoimmunity Reviews·Kenneth AbelAndreas Braun
May 11, 2006·American Journal of Human Genetics·Andrew E FryDominic P Kwiatkowski
Jul 15, 2004·American Journal of Human Genetics·Brian C Verrelli, Sarah A Tishkoff
Apr 24, 2015·The New Phytologist·Jason G BraggJustin O Borevitz
Apr 25, 2015·Animal Genetics·Ezequiel L NicolazziAlessandra Stella
Mar 18, 2016·Genome Biology and Evolution·Marte SodelandHalvor Knutsen
Sep 4, 2014·Animal Genetics·A L SomavillaLuciana Regitano
May 1, 2013·Asian-Australasian Journal of Animal Sciences·Dajeong LimSeung Hwan Lee
Jul 23, 2014·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·P StratzJ Bennewitz
Dec 3, 2014·Theoretical Population Biology·Hua ChenMontgomery Slatkin
Jun 10, 2015·Human Genetics·Bryony Leigh JonesDallas M Swallow
Jul 23, 2015·BMC Genomics·Qianqian ZhangGoutam Sahana
Apr 23, 2015·Molecular Biology and Evolution·Maxime BonhommeChristophe Jacquet
Nov 16, 2005·Annual Review of Genetics·Rasmus Nielsen
Jun 18, 2015·Frontiers in Genetics·Pablo Orozco-terWengelMichael W Bruford
Mar 20, 2015·Molecular Biology and Evolution·Ming-Shan WangYa-Ping Zhang
Apr 17, 2016·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Takashi AkagiRyutaro Tao