Detecting recurrent bladder cancer: new methods and biomarkers

Expert Review of Molecular Diagnostics
J S Ross, M B Cohen

Abstract

In this review, a series of biomarkers and molecular assays are compared with conventional urothelial cytology in their ability to detect recurrent bladder cancer. The tests considered in detail include the BTA test, NMP 22 test, DNA ploidy measurements, telomerase determinations and microsatellite instability assays. Although all of these measurements show some degree of improvement for cancer detection, the microsatellite instability assay shows the highest sensitivity and specificity. Additional biomarkers considered in the review include bladder cancer tumor antigens, growth factors, cell adhesion molecules and various molecular markers including cell cycle regulatory genes and p53 mutations.

References

Mar 12, 1992·The New England Journal of Medicine·D SidranskyB Vogelstein
Mar 1, 1989·Molecular and Cellular Endocrinology·G WildingE Gelmann
Oct 5, 1988·Journal of the National Cancer Institute·R GuirguisL Liotta
Mar 1, 1995·The Journal of Urology·M A Hudson, H W Herr
Jun 1, 1996·The Journal of Urology·J E CelisT F Orntoft
Sep 1, 1997·Seminars in Surgical Oncology·W H Foresman, E M Messing
Nov 20, 1997·The Journal of Urology·B JohnstonM Lundie
Feb 26, 1998·International Journal of Urology : Official Journal of the Japanese Urological Association·N MiyanagaK Koiso
Aug 12, 1998·International Journal of Cancer. Journal International Du Cancer·M ChristensenT F Orntoft
Aug 28, 1998·The Journal of Urology·J P SteinR J Cote
Dec 1, 1998·European Urology·F JankeviciusB J Schmitz-Dräger
Dec 8, 1998·International Journal of Cancer. Journal International Du Cancer·S MourahH Soliman
Jan 23, 1999·The Journal of Urology·S RamakumarD J O'Kane
Feb 4, 1999·American Journal of Clinical Pathology·J H Hughes, M B Cohen
Apr 21, 1999·The Journal of Urology·C MianM Marberger
Jul 16, 1999·Diagnostic Cytopathology·J F NasutiM Bibbo
Jan 4, 2001·Computer Methods and Programs in Biomedicine·H A Kestler

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Citations

Jul 19, 2005·Journal of Clinical Laboratory Analysis·Daniel Fatela-CantilloXavier Filella
Jan 17, 2012·Toxicon : Official Journal of the International Society on Toxinology·R C Cervantes CiancaV M Vasconcelos
Sep 24, 2004·Diagnostic Cytopathology·Laila Dahmoush, Michael B Cohen
Dec 20, 2007·Expert Review of Molecular Diagnostics·Aza MohammedAftab Bhatti

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