Detecting rejection in cardiac transplantation: applications of genomic medicine

Personalized Medicine
Rajeev Mohan, Jon Kobashigawa

Abstract

The primary focus of care in heart transplant recipients is to prevent rejection. Checking serum levels of immunosuppressant drugs as well as performing biopsies to obtain tissue samples for histological analysis have been the mainstays of rejection surveillance. Novel applications of genomics have proven to be useful in adding a noninvasive alternative to the standard of care. In particular, the use of gene-expression profiling to detect upregulation of rejection-related genes, detection of donor-derived cell-free DNA as a marker of graft apoptosis and rejection, as well as mRNA and miRNA as intragraft and peripheral markers of rejection have come to the forefront of genomics as they relate to transplantation. This review focuses on the use of genomics in heart transplant recipients.

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Citations

May 24, 2019·Circulation Research·Leslie MillerO H Frazier
Dec 6, 2016·Expert Review of Cardiovascular Therapy·Nicholas Furiasse, Jon A Kobashigawa
May 12, 2018·Personalized Medicine·Evan P Kransdorf, Jon A Kobashigawa

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Methods Mentioned

BETA
biopsies
biopsy
PCR
genotyping

Software Mentioned

AlloMap
CARGO

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis