Detecting retinal cell stress and apoptosis with DARC: Progression from lab to clinic.

Progress in Retinal and Eye Research
Maria Francesca CordeiroSaad Younis

Abstract

DARC (Detection of Apoptosing Retinal Cells) is a retinal imaging technology that has been developed within the last 2 decades from basic laboratory science to Phase 2 clinical trials. It uses ANX776 (fluorescently labelled Annexin A5) to identify stressed and apoptotic cells in the living eye. During its development, DARC has undergone biochemistry optimisation, scale-up and GMP manufacture and extensive preclinical evaluation. Initially tested in preclinical glaucoma and optic neuropathy models, it has also been investigated in Alzheimer, Parkinson's and Diabetic models, and used to assess efficacy of therapies. Progression to clinical trials has not been speedy. Intravenous ANX776 has to date been found to be safe and well-tolerated in 129 patients, including 16 from Phase 1 and 113 from Phase 2. Results on glaucoma and AMD patients have been recently published, and suggest DARC with an AI-aided algorithm can be used to predict disease activity. New analyses of DARC in GA prediction are reported here. Although further studies are needed to validate these findings, it appears there is potential of the technology to be used as a biomarker. Much larger clinical studies will be needed before it can be considered as a diagnostic,...Continue Reading

References

Nov 15, 1991·American Journal of Epidemiology·J M TielschA Sommer
Nov 22, 1991·Science·D HuangC A Puliafito
Jul 1, 1981·IEEE Transactions on Bio-medical Engineering·R H Webb, G W Hughes
Jul 1, 1995·Experimental Eye Research·E Garcia-ValenzuelaS C Sharma
Aug 1, 1997·Archives of Ophthalmology·L A KerriganM E Pease
Dec 14, 1999·European Journal of Nuclear Medicine·K OhtsukiH W Strauss
Mar 28, 2002·Physiological Reviews·Volker Gerke, Stephen E Moss
Nov 13, 2002·Archives of Ophthalmology·Joshua L DunaiefAnn H Milam
Mar 1, 2003·BMJ : British Medical Journal·Amresh ChopdarDinesh Verma
Apr 17, 2003·Current Opinion in Ophthalmology·Douglas R Anderson, UNKNOWN Normal Tension Glaucoma Study
Jul 11, 2003·Survey of Ophthalmology·Richard F Brubaker
Jul 19, 2003·Nuclear Medicine Communications·C M M LahorteR A Dierckx
Sep 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christophe van de WieleRudi A Dierck
Dec 11, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Yoshihiro MurakamiShintaro Nishimura
Apr 20, 2004·Nuclear Medicine Communications·Hubert VermeerschChristophe Van de Wiele
Jun 9, 2004·International Journal of Radiation Oncology, Biology, Physics·Rick L M HaasMarcel Verheij
Sep 1, 2004·Biochemical and Biophysical Research Communications·Matthew J Hayes, Stephen E Moss
Sep 15, 2004·American Journal of Ophthalmology·Robert N WeinrebWilliam B Kannel
Dec 30, 2004·Investigative Ophthalmology & Visual Science·Li GuoM Francesca Cordeiro
Apr 19, 2005·The British Journal of Ophthalmology·F K MalerbiR Susanna
Jan 25, 2006·Investigative Ophthalmology & Visual Science·Li GuoM Francesca Cordeiro
Feb 16, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Francis G BlankenbergMidori Anne Yenari
Feb 21, 2006·The British Journal of Ophthalmology·H A Quigley, A T Broman
Mar 7, 2006·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Pervin K IseriNurşen Yüksel
Apr 6, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Marina S KartachovaMarcel Verheij
Aug 2, 2006·Journal of Pineal Research·Guillermo García-SantosCarmen Rodriguez
Nov 1, 2006·Experimental Eye Research·David ReichsteinJohn Danias
Nov 30, 2006·The Journal of Biological Chemistry·David L Daleke
Apr 3, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Bas L J H KietselaerLeo Hofstra
May 2, 2007·The Journal of Biological Chemistry·Krishnakumar BalasubramanianAlan J Schroit
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marina KartachovaRenato Alfredo Valdés Olmos
Aug 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·Li GuoM Francesca Cordeiro
Nov 13, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Frank J P HoebersMarcel Verheij

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Aug 17, 2021·Current Opinion in Neurobiology·Lieve Moons, Lies De Groef

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