Detecting selection signatures between Duroc and Duroc synthetic pig populations using high-density SNP chip

Animal Genetics
Z EdeaK-S Kim

Abstract

The development of high throughput genotyping techniques has facilitated the identification of selection signatures of pigs. The detection of genomic selection signals in a population subjected to differential selection pressures may provide insights into the genes associated with economically and biologically important traits. To identify genomic regions under selection, we genotyped 488 Duroc (D) pigs and 155 D × Korean native pigs (DKNPs) using the Porcine SNP70K BeadChip. By applying the FST and extended haplotype homozygosity (EHH-Rsb) methods, we detected genes under directional selection associated with growth/stature (DOCK7, PLCB4, HS2ST1, FBP2 and TG), carcass and meat quality (TG, COL14A1, FBXO5, NR3C1, SNX7, ARHGAP26 and DPYD), number of teats (LOC100153159 and LRRC1), pigmentation (MME) and ear morphology (SOX5), which are all mostly near or at fixation. These results could be a basis for investigating the underlying mutations associated with observed phenotypic variation. Validation using genome-wide association analysis would also facilitate the inclusion of some of these markers in genetic evaluation programs.

References

Jun 4, 1999·Trends in Neurosciences·D M Fekete
Aug 22, 2000·The Journal of Investigative Dermatology·E AberdamR Ballotti
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Jul 1, 2006·Trends in Genetics : TIG·Shameek Biswas, Joshua M Akey
Jan 8, 2011·Genetics·Jennie E PryceMichael E Goddard
Feb 22, 2012·PLoS Biology·James W KijasUNKNOWN International Sheep Genomics Consortium Members
Mar 4, 2014·PLoS Genetics·Saber QanbariHenner Simianer
Mar 26, 2014·Journal of Animal Science·L FontanesiV Russo
Aug 12, 2014·Journal of Applied Genetics·L L VerardoS E F Guimarães
Jun 20, 2015·Genetics, Selection, Evolution : GSE·Fuping ZhaoDonagh P Berry
Nov 1, 1984·Evolution; International Journal of Organic Evolution·B S Weir, C Clark Cockerham

❮ Previous
Next ❯

Citations

Oct 24, 2017·Asian-Australasian Journal of Animal Sciences·Jianping QuanJie Yang
May 28, 2020·Frontiers in Genetics·Nompilo Lucia HlongwaneFarai Catherine Muchadeyi
Sep 9, 2020·Asian-Australasian Journal of Animal Sciences·Joon Ki HongSoo Jin Sa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.