Detecting synfire chains in parallel spike data

Journal of Neuroscience Methods
George L GersteinChris Trengove

Abstract

The synfire chain model of brain organization has received much theoretical attention since its introduction (Abeles, 1982, 1991). However there has been no convincing experimental demonstration of synfire chains due partly to limitations of recording technology but also due to lack of appropriate analytic methods for large scale recordings of parallel spike trains. We have previously published one such method based on intersection of the neural populations active at two different times (Schrader et al., 2008). In the present paper we extend this analysis to deal with higher firing rates and noise levels, and develop two additional tools based on properties of repeating firing patterns. All three measures show characteristic signatures if synfire chains underlie the recorded data. However we demonstrate that the detection of repeating firing patterns alone (as used in several papers) is not enough to infer the presence of synfire chains. Positive results from all three measures are needed.

References

Jan 1, 1996·Journal of Physiology, Paris·A AertsenM O Gewaltig
Jan 1, 1996·Journal of Physiology, Paris·M Abeles, Y Prut
Oct 21, 2000·Journal of Neuroscience Methods·G L Gerstein
Jun 8, 2001·Journal of Neuroscience Methods·M Abeles, I Gat
Oct 23, 2001·Neural Networks : the Official Journal of the International Neural Network Society·M O GewaltigA Aertsen
Apr 16, 2003·Methods : a Companion to Methods in Enzymology·Thomas KnöpfelRieko Sakai
May 17, 2003·Biological cybernetics·Carsten MehringAd Aertsen
Jun 21, 2003·Neural Computation·Y AvielD Horn
Aug 9, 2003·Journal of Neurophysiology·Jozsef CsicsvariGyörgy Buzsáki
Aug 13, 2004·Journal of Computational Neuroscience·Moshe AbelesDaniel Lehmann
Nov 1, 1949·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·C O HEBB, H KONZETT
Feb 25, 2005·Nature·Yumiko YoshimuraEdward M Callaway
Mar 25, 2005·Journal of Computational Neuroscience·Gaby HayonDaniel Lehmann
Dec 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Tomer ShmielMoshe Abeles
Dec 28, 2005·Neural Computation·Eugene M Izhikevich
Aug 4, 2006·Journal of Neurophysiology·Tomer ShmielMoshe Abeles
Aug 24, 2006·Journal of Computational Neuroscience·Antonio Pazienti, Sonja Grün
Dec 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Artur LuczakKenneth D Harris
Mar 20, 1964·Science·G L Gerstein, W A Clark
Nov 17, 2007·Science·David R EustonBruce L McNaughton
Jul 18, 2008·Journal of Neurophysiology·Sven SchraderGeorge L Gerstein
Jun 18, 2010·Neural Networks : the Official Journal of the International Neural Network Society·Sebastien LouisSonja Grün
Nov 10, 2010·Frontiers in Computational Neuroscience·Sebastien LouisMarkus Diesmann
Jan 25, 2011·Frontiers in Computational Neuroscience·Sven SchraderAbigail Morrison

❮ Previous
Next ❯

Citations

Aug 11, 2012·Journal of Computational Neuroscience·Chris TrengoveMarkus Diesmann
Sep 27, 2014·Journal of Neuroscience Methods·Alister U NicolMagnus S Magnusson
Jul 16, 2016·PLoS Computational Biology·Emiliano TorreSonja Grün
Jan 12, 2017·ELife·Eleonora Russo, Daniel Durstewitz
Oct 7, 2017·International Journal of Neural Systems·Felix WeissenbergerAngelika Steger
Apr 14, 2018·Biological cybernetics·Pietro QuaglioSonja Grün
Sep 14, 2016·Bioinspiration & Biomimetics·Jacob EngelmannLeonel Gómez-Sena
Nov 24, 2018·Frontiers in Neuroinformatics·Johanna SenkBenjamin Weyers
Sep 17, 2014·Learning & Memory·Evan S HillWilliam N Frost

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Computational Neuroscience
Chris TrengoveM Diesmann
Frontiers in Computational Neuroscience
Sven SchraderAbigail Morrison
Journal of Computational Neuroscience
Alexander HanuschkinM Diesmann
© 2022 Meta ULC. All rights reserved