Detecting the emergence of chronic pain in sickle cell disease.

Journal of Pain and Symptom Management
Mark HollinsK M Gil

Abstract

Sickle cell disease (SCD) is an inherited hematological disease marked by intense pain. Early in life the pain is episodic, but it becomes increasingly chronic in many cases. Little is known about this emergence of a chronic pain state. The goal of this study was to determine whether adult SCD patients whose pain is still largely episodic show early signs of the disturbed pain processing (hyperalgesia and increased temporal summation) and cognition (hypervigilance and catastrophizing) that are characteristic of a chronic pain state. SCD patients (n=22) and healthy controls (n=52) received noxious pressure stimulation for up to three minutes and periodically reported pain intensity and unpleasantness on 0-10 scales, allowing the rate of pain increase (temporal summation) to be determined. Pain intensity discrimination also was measured, and attitudes toward pain were assessed. There were no overall differences in pain ratings or temporal summation between patient and control groups. However, patients' experimental pain ratings tended to increase with age and those reporting a history of very painful episodes showed particularly rapid temporal summation of pain unpleasantness. Patients were significantly impaired at discriminatin...Continue Reading

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Citations

Aug 15, 2013·Clinical Nurse Specialist CNS·Deborah HanesJanine Overcash
Jul 25, 2014·Journal of Pain and Symptom Management·Shan-Estelle BrownWilliam H Sledge
May 16, 2015·Pediatric Blood & Cancer·Amanda M BrandowJulie A Panepinto
Feb 26, 2016·Journal of Pediatric Hematology/oncology·Amanda M Brandow, Julie A Panepinto
Dec 4, 2014·Blood Cells, Molecules & Diseases·Nara GaviniManjit Hanspal
Jun 7, 2016·The Journal of Pain : Official Journal of the American Pain Society·Soumitri SilLindsey L Cohen
Aug 25, 2016·The Journal of Pain : Official Journal of the American Pain Society·Vani A MathurClaudia M Campbell
Nov 24, 2016·American Journal of Hematology·Charlotte F J van TuijnBart J Biemond
Apr 3, 2014·Perception·Mark HollinsDaniel Harper
Dec 10, 2017·Hematology·Deepika S Darbari, Amanda M Brandow
Aug 1, 2019·Expert Review of Hematology·Carlton Dampier
Jul 6, 2019·The Cochrane Database of Systematic Reviews·Monika R AsnaniAmza Ali
Aug 28, 2019·Neuroscience Letters·Deva Sharma, Amanda M Brandow
May 26, 2020·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Rae Ann Kingsley

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