Detection and aggregation of the antitumoral drug parietin in ethanol/water mixture and on plasmonic metal nanoparticles studied by surface-enhanced optical spectroscopy: Effect of pH and ethanol concentration

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Eduardo Lopez-TobarS Sanchez-Cortes

Abstract

In the present paper, we have investigated the effect of ethanol in aqueous media, the pH and the presence of Ag nanoparticles (NPs) on the aggregation processes of the antitumoral anthraquinone parietin in aqueous media and on the metal surface. UV-visible absorption, fluorescence and Raman spectra of parietin were used for such purpose. The present study provides information about the deprotonation and molecular aggregation processes occurring in parietin under different environments: ethanol/water mixture and when adsorbed onto Ag nanoparticles. The effect of ethanol on the optical properties of parietin in alcohol-water mixtures was also investigated at different ethanol concentrations with the time. For the case of the adsorption and organization of parietin molecules on the surface of Ag NPs, special attention was paid to the use of surface-enhanced optical techniques, SEF (surface-enhanced fluorescence) and SERS (surface-enhanced Raman scattering), for the characterization of the parietin aggregates and the ionization of the molecule on the surface. In particular, we have studied the variation of the SEF signal with the pH, which depends on the molecular organization of the molecule on the surface. Furthermore, a detaile...Continue Reading

References

Jul 21, 2006·The Journal of Physical Chemistry. B·Sergei Yu NoskovBenoît Roux
Sep 15, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M BačkorováP Fedoročko
Sep 29, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·Lewis E ScottChristopher A Lemmon

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Citations

Dec 16, 2016·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Laura R CominiClaudio D Borsarelli
Jan 8, 2019·The International Journal of Lower Extremity Wounds·Gulsah GundogduAhmet Hacimuftuoglu
Dec 4, 2020·Journal of Photochemistry and Photobiology. B, Biology·María Laura MugasAdriana Casas

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