Detection and characterization of focal hepatic lesions: mangafodipir vs. superparamagnetic iron oxide-enhanced magnetic resonance imaging

Journal of Magnetic Resonance Imaging : JMRI
Myeong-Jin KimKi Whang Kim

Abstract

To compare the mangafodipir-enhanced magnetic resonance (MR) and superparamagnetic iron oxide (SPIO)-enhanced images for their ability to detect and characterize focal hepatic lesions. Unenhanced, mangafodipir-enhanced, and SPIO-enhanced hepatic MR images obtained from 64 patients were analyzed. A total of 121 hepatic lesions were included: 66 hepatocellular carcinomas (HCCs), 26 metastases, 14 hemangiomas, 5 cysts, 3 cholangiocarcinomas, 4 focal nodular hyperplasias (FNHs), 2 abscesses, and 1 adenoma. Two radiologists independently reviewed the two sets of images in a random order: 1) the unenhanced and mangafodipir-enhanced images (the mangafodipir set) and 2) the unenhanced and SPIO-enhanced images (the SPIO set). This study compared the accuracy of lesion detection, the ability to distinguish between a benign and malignant lesion, and the ability to distinguish between the hepatocellular and nonhepatocellular origins of the lesions using the areas (Az) under the receiver operating characteristic (ROC) curve. The overall accuracy for detecting focal lesions was significantly higher (P < 0.05) with the SPIO set (Az = 0.846 and 0.871 for readers 1 and 2, respectively) than with the mangafodipir set (Az = 0.716 and 0.766). Most...Continue Reading

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Citations

Aug 7, 2008·European Radiology·Priyanka JhaHeike Daldrup-Link
Jun 13, 2006·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·J Ward
Feb 22, 2012·Contrast Media & Molecular Imaging·Michael HodeniusFabian Kiessling
Jul 4, 2007·Surgical Oncology Clinics of North America·Donald L Klippenstein, Dominick M Lamonica
Aug 22, 2006·European Journal of Radiology·Jin-Young ChoiKi Whang Kim
Jun 17, 2006·Academic Radiology·Elizaveta ChabanovaHenrik S Thomsen
Jan 4, 2017·Chemical Reviews·Bryan Ronain Smith, Sanjiv Sam Gambhir
Feb 25, 2011·European Journal of Gastroenterology & Hepatology·Carlo FiliceGiovanna Ferraioli
Mar 14, 2007·Journal of Magnetic Resonance Imaging : JMRI·James F Glockner

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