Detection and characterization of nanoparticles in suspension at low concentrations using the X-ray total scattering pair distribution function technique

Nanoscale
Maxwell W TerbanSimon J L Billinge

Abstract

Difference atomic pair distribution function methods have been applied to detect and characterize nanoparticles suspended in a solvent at very dilute concentrations. We specifically consider nanoparticles of a pharmaceutical compound in aqueous solution using X-ray PDF methods, a challenging case due to the low atomic number of the nanoparticle species. The nanoparticles were unambiguously detected at the level of 0.25 wt%. Even at these low concentrations the signals were highly reproducible, allowing for reliable detection and quantitative analysis of the nanoparticle structure.

References

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Citations

Dec 25, 2015·Acta Crystallographica. Section A, Foundations and Advances·Dragica PrillMartin U Schmidt
Jul 2, 2015·Acta Crystallographica. Section A, Foundations and Advances·L GranlundP M Duxbury
Nov 4, 2016·Acta Crystallographica. Section A, Foundations and Advances·Mirijam Zobel
Nov 4, 2016·Acta Crystallographica. Section A, Foundations and Advances·Federica BertolottiNorberto Masciocchi
May 1, 2019·AAPS PharmSciTech·Stephen R ByrnPamela A Smith
Apr 30, 2019·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Simon J L Billinge
Oct 31, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Hany A El-SayedHubert A Gasteiger
Nov 18, 2021·Chemical Reviews·Maxwell W Terban, Simon J L Billinge

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