PMID: 8992203Apr 1, 1996Paper

Detection and characterization of primary liver cancer in rats by MS-264-enhanced MRI

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
C PetréA L Baert

Abstract

A new MR contrast agent, MS-264 (Gd(1RS)-1-(p-butylbenzyl)-DTPA), was developed to achieve hepatobiliary specificity and its potential evaluated for detecting and characterizing liver tumors in rats with chemically induced hepatocellular carcinoma (HCC). In seven rats with 66 HCC lesions, enhancements of different abdominal organs and tumors were compared on T1-weighted images after intravenous administration of Gd-DTPA (0.3 mmol/kg) and MS-264 (0.05 mmol/kg). MR images were correlated with postmortem microangiographic and histological findings. An overall enhancement of different organs, which normalized within 24 h, was observed after Gd-DTPA and MS-264 injection. MS-264 caused a higher relative enhancement (RE) in liver (60%), compared with that of Gd-DTPA (40%), which resulted in a prompt negative contrast enhancement in 59 of 66 HCCs. All were moderately to poorly differentiated (Grades II-IV) tumors. Six of these 59 negative contrast-enhancing lesions showed a positively enhanced peritumoral rim, which corresponded histologically to malignant infiltration (n = 2) or compression (n = 4). On the other hand, six well differentiated HCCs showed prolonged positive enhancement. However, one well differentiated HCC was not posit...Continue Reading

References

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Citations

Jun 6, 2000·Advanced Drug Delivery Reviews·Y Okuhata
Mar 22, 2003·European Journal of Radiology·Hanns-Joachim WeinmannHeribert Schmitt-Willich
Sep 25, 2004·Journal of Magnetic Resonance Imaging : JMRI·Jui-Sheng HsuKun-Bow Tsai
Feb 15, 2001·Investigative Radiology·M LewinG Frija

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