Detection and characterization of rotaviruses in hospitalized neonates in Blantyre, Malawi.

Journal of Clinical Microbiology
N A CunliffeC A Hart

Abstract

In five separate fecal collections spanning three years, group A rotaviruses were detected by enzyme-linked immunosorbent assay in 35 (25%) of 142 specimens obtained from nondiarrheic, hospitalized neonates in Blantyre, Malawi. Molecular characterization of each strain identified, for the first time in neonates, a short electropherotype, genotype P[6], G8 strain type, similar to the dominant, cocirculating community strain detected in symptomatic infants in Blantyre. Partial sequence analysis of the VP4 and NSP4 genes of neonatal and community strains failed to identify changes which could explain the differences in clinical outcome. Neonatal serotype G8 rotaviruses should be considered as potential rotavirus vaccine candidates for use in Malawi.

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Citations

Jan 7, 2006·The Pediatric Infectious Disease Journal·Ulrich DesselbergerTimo Vesikari
Jul 5, 2008·The Pediatric Infectious Disease Journal·Sasirekha RamaniGagandeep Kang
May 8, 2003·Journal of Clinical Microbiology·Mustafizur RahmanMarc Van Ranst
May 5, 2006·Journal of Clinical Microbiology·Jelle MatthijnssensMarc Van Ranst
May 19, 2006·Emerging Infectious Diseases·Rita Cássia Compagnoli CarmonaLeonardo José Richtzenhain
Mar 30, 2010·Malawi Medical Journal : the Journal of Medical Association of Malawi·Nigel CunliffeBagrey Ngwira
Feb 22, 2012·Pediatrics and Neonatology·Jung Ok ShimYeon-Chang Jung
May 4, 2004·Journal of Medical Virology·B KhaliliC A Hart
Dec 18, 2013·The Pediatric Infectious Disease Journal·Brenda A KwambanaMartin Antonio
Mar 22, 2007·Journal of Medical Microbiology·Joana D'Arc P MascarenhasAlexandre C Linhares

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