Detection and compensation of dispersion mismatch for frequency-domain optical coherence tomography based on A-scan's spectrogram

Optics Express
Guangming NiYong Liu

Abstract

Balanced dispersion between reference and sample arms is critical in frequency-domain optical coherence tomography (FD-OCT) to perform imaging with the optimal axial resolution, and the spectroscopic analysis of each voxel in FD-OCT can provide the metric of the spectrogram. Here we revisited dispersion mismatch in the spectrogram view using the spectroscopic analysis of voxels in FD-OCT and uncovered that the dispersion mismatch disturbs the A-scan's spectrogram and reshapes the depth-resolved spectra in the spectrogram. Based on this spectroscopic effect of dispersion mismatch on A-scan's spectrogram, we proposed a numerical method to detect dispersion mismatch and perform dispersion compensation for FD-OCT. The proposed method can visually and quantitatively detect and compensate for dispersion mismatch in FD-OCT, with visualization, high sensitivity, and independence from sample structures. Experimental results of tape and mouse eye suggest that this technique can be an effective method for the detection and compensation of dispersion mismatch in FD-OCT.

References

Nov 22, 1991·Science·D HuangC A Puliafito
Jun 7, 2003·Applied Optics·Daniel L MarksStephen A Boppart
Apr 24, 2004·Physics in Medicine and Biology·Bin LiuMark E Brezinski
Dec 13, 2007·Optics Letters·W DrexlerJ G Fujimoto
Jan 9, 2009·Optics Express·Bernd HoferWolfgang Drexler
Dec 4, 2013·Biomedical Optics Express·Nienke BosschaartDirk J Faber
Sep 13, 2017·Computers in Biology and Medicine·Guangming NiShi Chen
Sep 16, 2019·IScience·Xin GeLinbo Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Imaging in CNS

Here is the latest research on cell imaging and imaging modalities, including light-sheet microscopy, in the central nervous system.