Detection and Distinction of Mild Brain Injury Effects in a Ferret Model Using Diffusion Tensor MRI (DTI) and DTI-Driven Tensor-Based Morphometry (D-TBM)

Frontiers in Neuroscience
E B HutchinsonC Pierpaoli

Abstract

Mild traumatic brain injury (mTBI) is highly prevalent but lacks both research tools with adequate sensitivity to detect cellular alterations that accompany mild injury and pre-clinical models that are able to robustly mimic hallmark features of human TBI. To address these related challenges, high-resolution diffusion tensor MRI (DTI) analysis was performed in a model of mild TBI in the ferret - a species that, unlike rodents, share with humans a gyrencephalic cortex and high white matter (WM) volume. A set of DTI image analysis tools were optimized and implemented to explore key features of DTI alterations in ex vivo adult male ferret brains (n = 26), evaluated 1 day to 16 weeks after mild controlled cortical impact (CCI). Using template-based ROI analysis, lesion overlay mapping and DTI-driven tensor-based morphometry (D-TBM) significant differences in DTI and morphometric values were found and their dependence on time after injury evaluated. These observations were also qualitatively compared with immunohistochemistry staining of neurons, astrocytes, and microglia in the same tissue. Focal DTI abnormalities including reduced cortical diffusivity were apparent in 12/13 injured brains with greatest lesion extent found acutely ...Continue Reading

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Citations

Jul 17, 2019·Journal of Experimental Neuroscience·Wouter S HoogenboomMichael L Lipton
Feb 20, 2020·Military Medicine·Palamadai N VenkatasubramanianJoachim Spiess
Aug 28, 2020·Human Brain Mapping·Samuel St-JeanAlexander Leemans
Nov 24, 2020·NeuroImage·Adam MessingerP Christiaan Klink
Jan 18, 2021·Brain : a Journal of Neurology·Cornelius K DonatMazdak Ghajari
Dec 14, 2021·Frontiers in Neuroscience·Karthik CharyAlejandra Sierra

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Methods Mentioned

BETA
NMR

Software Mentioned

TORTOISE
Zen
ITKsnap
DRTAMAS
TBM
ANTs
TORTOISE3
Trace
DIFFCALC
R package

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