Detection and distribution of the carbohydrate binding protein galectin-3 in human notochord, intervertebral disc and chordoma

Differentiation; Research in Biological Diversity
W GötzR C Hughes

Abstract

Galectin-3 is an endogenous carbohydrate-binding protein which plays a role in cell differentiation, morphogenesis and cancer biology. We investigated the occurrence and distribution of galectin-3 in the embryonic and fetal human notochord, the developing human vertebral column, adult intervertebral discs and in six chordomas, which are tumors thought to originate from notochordal remnants. By means of Western blots, the expression of galectin-3 was confirmed in tissue probes from the vertebral column region beginning with the 8th gestational week. These results were supported by immunohistochemical data which revealed the presence of galectin-3 in the cytoplasm of cells of the notochord also from the 8th gestational week onwards. Notochordal immunostaining became stronger with increasing gestational age. A persisting notochordal remnant in an adult intervertebral disc and various cells of the nucleus pulposus also contained galectin-3. All chordomas showed moderate or strong immunoreactivity irrespective of their cellular composition. Subcellularly, galectin-3 was localized mostly in the cytoplasm, while a subset of tumor cells also showed nuclear distribution. Differences in staining patterns of chordoma cells could not, in g...Continue Reading

References

Jan 1, 1989·Current Topics in Pathology. Ergebnisse Der Pathologie·V BouropoulouA Härle
Apr 1, 1988·The Anatomical Record·M D Humzah, R W Soames
Aug 1, 1987·Cell Differentiation·N S Vasan
Jan 1, 1994·American Journal of Clinical Pathology·A E RosenbergJ M Lee
Jun 1, 1995·Journal of Neurochemistry·R ProbstmeierM Schachner
Aug 1, 1995·Current Opinion in Genetics & Development·M Placzek
Jun 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D FowlisF Poirier
May 1, 1995·Neuroradiology·A CottenJ Clarisse
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M M LotzA M Mercurio
May 1, 1995·Cell and Tissue Research·W GötzR Herken
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·S F DagherR J Patterson
Dec 1, 1993·The Journal of Pathology·J R Salisbury
Feb 1, 1996·Biochemical Society Transactions·C ColnotF Poirier
May 1, 1996·The Journal of Pathology·V CastronovoM E Sobel
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·R Y YangF T Liu
Jul 1, 1996·Virchows Archiv : an International Journal of Pathology·M KasperM Müller
Nov 15, 1996·Science·Y Tanabe, T M Jessell
Jul 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M Nurminskaya, T F Linsenmayer
Dec 1, 1996·Journal of Cellular Physiology·J E AubinK Turksen
Jan 1, 1997·The Journal of Pathology·P L FernándezM E Sobel
Feb 1, 1997·Glycoconjugate Journal·S Dong, R C Hughes

❮ Previous
Next ❯

Citations

Apr 8, 2010·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Christoph WeilerNorbert Boos
Dec 31, 2003·Methods : a Companion to Methods in Enzymology·Philip A Pemberton, Phillip I Bird
Jan 1, 2005·Hereditary Cancer in Clinical Practice·Lidia LarizzaPaola Riva
Apr 30, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Ricardo Rodrigues-PintoJudith A Hoyland
Oct 29, 2014·Archives of Orthopaedic and Trauma Surgery·G W OmlorT Guehring
Sep 29, 2011·The Orthopedic Clinics of North America·Wilson C W ChanDanny Chan
Sep 22, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Jun ShenMin Deng
Feb 13, 2009·International Journal of Pediatric Otorhinolaryngology·Tal MaromYehudah Roth
Dec 8, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Ye TianMakarand V Risbud
Jun 27, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yan ZengMakarand V Risbud
Jun 14, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Liufang JingJun Chen
Jun 13, 2012·Journal of Anatomy·Girish PattappaSibylle Grad
Mar 27, 2016·Gene·Sukru GulluogluOmer Faruk Bayrak
Mar 17, 2001·Acta histochemica·W Götz, F Quondamatteo
Sep 7, 2014·Biochimica Et Biophysica Acta·Youssef YakkiouiYasin Temel
Feb 26, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ricardo Rodrigues-PintoJudith A Hoyland
May 23, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Mahmoud ElshamlyStefan Toegel
Feb 27, 2003·The Journal of Biological Chemistry·Michael StockFlorian Otto
Sep 14, 2015·Neurosurgical Review·Sukru GulluogluOmer Faruk Bayrak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Developmental Dynamics : an Official Publication of the American Association of Anatomists
K H HealyD K Darnell
Developmental Dynamics : an Official Publication of the American Association of Anatomists
J W StevensJ A Maynard
Differentiation; Research in Biological Diversity
P StosiekU Karsten
© 2021 Meta ULC. All rights reserved