Detection and evaluation of p53 intron 2 polymorphism in lung carcinomas in Hong Kong

International Journal of Cancer. Journal International Du Cancer
H GeM L Lung

Abstract

A polymorphism in intron 2 of the p53 gene, which gives rise to 2 alleles, A1 and A2, was analyzed by polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and direct DNA-sequencing techniques. The distribution of this allele in the peripheral blood in the Chinese population comprising 27 healthy individuals, 30 bronchiectasis patients, 34 non-small-cell lung cancer (NSCLC) patients and 27 SCLC patients was analyzed. The genotypic distributions for this marker were significantly different between the blood of healthy individuals and SCLC patients. There was no significant difference between genotypes of Caucasians and Chinese. Tumors, normal lungs and peripheral blood of 83 adenocarcinoma and 10 squamous cell carcinoma patients were also studied. There was a significant difference in the distribution of the genotypes detected in tumor tissues vs. blood of adenocarcinoma patients. The frequency of detection of the A1/A1 genotype in the tumor tissues was increased in adenocarcinoma patients as compared with the blood of adenocarcinoma patients and was decreased in the blood of SCLC patients as compared with the blood of healthy individuals. Survival rates in Hong Kong adenocarcinoma patients with the A1/A1 ...Continue Reading

References

Nov 1, 1992·Environmental Health Perspectives·A WestonC C Harris
Jul 2, 1992·Nature·G FarmerC Prives
Jul 5, 1991·Science·M HollsteinC C Harris
Jul 1, 1990·The Journal of Clinical Investigation·T TakahashiJ D Minna
Jan 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H C HsuS W Lin
Apr 1, 1994·International Journal of Cancer. Journal International Du Cancer·T SoussiB Schlichtholz
May 1, 1994·Human Genetics·L M Pleasants, M F Hansen

❮ Previous
Next ❯

Citations

Jun 18, 2005·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·José Luis Soto MartínezMiguel Angel López-Nevot
Sep 2, 2005·Respirology : Official Journal of the Asian Pacific Society of Respirology·Wah Kit Lam

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.