Detection and Evaluation of Renal Injury in Burst Wave Lithotripsy Using Ultrasound and Magnetic Resonance Imaging

Journal of Endourology
Philip C MayMathew D Sorensen

Abstract

Burst wave lithotripsy (BWL) is a transcutaneous technique with potential to safely and effectively fragment renal stones. Preclinical investigations of BWL require the assessment of potential renal injury. This study evaluates the capabilities of real-time ultrasound and MRI to detect and evaluate BWL injury that was induced in porcine kidneys. Ten kidneys from five female farm pigs were treated with either a 170 or 335 kHz BWL transducer using variable treatment parameters and monitored in real-time with ultrasound. Eight kidneys were perfusion fixed and scanned with a 3-Tesla MRI scanner (T1-weighted, T2-weighted, and susceptibility-weighted imaging), followed by processing via an established histomorphometric technique for injury quantification. In addition, two kidneys were separately evaluated for histologic characterization of injury quality. Observed B-mode hyperechoes on ultrasound consistent with cavitation predicted the presence of BWL-induced renal injury with a sensitivity and specificity of 100% in comparison to the histomorphometric technique. Similarly, MRI detected renal injury with a sensitivity of 90% and specificity of 100% and was able to identify the scale of lesion volumes. The injuries purposefully gener...Continue Reading

Associated Clinical Trials

Mar 15, 2021·Jonathan Harper, MD

References

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Citations

Feb 13, 2018·Journal of Endourology·Theresa A ZwaschkaAdam D Maxwell
Apr 25, 2019·Journal of Endourology·Adam D MaxwellMathew D Sorensen
Nov 15, 2019·Current Opinion in Urology·Spencer C Hiller, Khurshid R Ghani
Jan 7, 2020·Current Opinion in Urology·Tony T ChenMichael R Bailey
Sep 18, 2020·Journal of Endourology·Jonathan D HarperMathew D Sorensen
Apr 3, 2020·The Journal of the Acoustical Society of America·Adam D MaxwellOleg A Sapozhnikov
Dec 14, 2018·The Journal of the Acoustical Society of America·Kazuki MaedaMichael R Bailey
Feb 28, 2020·Journal of Endourology·Shivani RameshMichael R Bailey
Aug 6, 2020·The Journal of the Acoustical Society of America·Akshay RandadAdam D Maxwell
Aug 3, 2017·Der Urologe. Ausg. A·A Neisius
Jun 4, 2021·Ultrasound in Medicine & Biology·Adam D MaxwellYak-Nam Wang

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