Detection and genotyping of enteric viruses in hospitalized children with acute gastroenteritis in Belém, Brazil: Occurrence of adenovirus viremia by species F, types 40/41

Journal of Medical Virology
Thayara Morais PortalYvone Benchimol Gabbay

Abstract

Enteric adenovirus (AdV), sapovirus (SaV), and human astrovirus (HAstV) are important pathogens involved in the gastroenteritis etiology. In this study, a total of 219 fecal samples and sera were collected from children hospitalized for acute gastroenteritis (AGE) in two large pediatric hospitals in Belém, from March 2012 to April 2015. The samples were analyzed by polymerase chain reaction (PCR) for AdV and HAstV (astrovirus) detection, and Nested-PCR and qPCR for SaV detection. AdV was detected in 50.2% (110/219) of the cases, with 42.7% (47/110) being sequenced and classified as: species F (63.9% - 30/47), A (4.2% - 2/47), B (6.4% - 3/47), C (17.1% - 8/47), D (4.2% - 2/47), and E (4.2% - 2/47). Of the 110 AdV-positive feces samples, 80 paired sera presented sufficient amounts and were also tested for this virus, of which 51 (63.7%) showed positive results and 26 (70.3%) pairs (feces plus sera) presented concordant results after sequencing being classified as: species F (21/26; 80.8%), A (1/26; 3.8%), B (1/26; 3.8%), and C (3/26; 11.5%). Overall, HAstV rate in the feces samples was 1.8% (4/219), including both HAstV-1a (2/4; 50%) and HAstV-2c (2/4; 50%). SaV was detected in 4.6% (10/219) of the fecal samples, out of which 50%...Continue Reading

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Citations

Jul 7, 2019·Scientific Reports·Jianfang YangWenbo Xu
Aug 17, 2020·Current Opinion in Infectious Diseases·Sylvia Becker-DrepsFilemón Bucardo
Aug 11, 2020·Current Opinion in Infectious Diseases·Benjamin LeeJames A Platts-Mills
Apr 29, 2019·The Science of the Total Environment·Jennifer H LunPeter A White
Jul 23, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Yasmin França Viana Pires de SouzaAdriana Luchs
May 31, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Alberto Ignacio Olivares OlivaresMarcia Terezinha Baroni de Moraes
Aug 29, 2021·Pathogens·Marcia Terezinha Baroni de MoraesJohan Nordgren

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