Detection and genotyping of human papillomavirus (HPV) in HIV-infected women and its relationship with HPV/HIV co-infection

Medicine
Rodolfo Miglioli BadialPaula Rahal

Abstract

HPV have been identified as high-risk and low-risk, depending on their association with the development of cancer. HPV infections can be facilitated by co-infection with HIV. Here, we investigated HPV prevalence and genotypes and the risk factors affecting HPV/HIV co-infection. Forty HIV-positive patients had 80 cervical swab samples collected in 2 consecutive years. Polymerase chain reaction and DNA direct sequencing were used to perform HPV genotyping. Statistical analyses were performed regarding risk factors for HPV/HIV co-infection and the occurrence of cervical lesions. HPV DNA was detected in 59 samples (73.75%), and high-risk HPVs were predominant (59.3%). The most prevalent type was HPV56 (17%), followed by HPV16 (15.3%). Patient age did not affect the risk of cervical cancer (P = .84) or HPV prevalence in different years (P = .25/P = .63). CD4 count also did not affect the risk for cervical lesions in the tested samples (P = .15/P = .28). Although the HIV viral load was not correlated with an increase in cervical lesion detection in the first group of analyzed samples (P = .12), it did affect cervical cancer risk in the group of samples analyzed in the following year (P = .045). HIV-infected patients presented a high ...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Mar 4, 2000·JAMA : the Journal of the American Medical Association·T V EllerbrockT C Wright
Apr 5, 2002·Genome Research·W James Kent
Aug 31, 2002·Journal of Clinical Microbiology·Joeli A BrinkmanMichael E Hagensee
Oct 19, 2004·Journal of Virological Methods·Andrea L Fuessel HawsStephen K Tyring
Feb 16, 2008·International Journal of STD & AIDS·Päivi LehtovirtaOskari Heikinheimo
Apr 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gaëlle A V BouletJohannes Bogers
May 26, 2009·BMC Clinical Pathology·Sin Hang LeeSuri Pappu
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Mar 23, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Anna Rosa GarbugliaMaria Rosaria Capobianchi
Mar 27, 2012·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Angela C L AraújoVictor H Melo
Nov 6, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·I HeardUNKNOWN MACH-1 Study Group
Jul 9, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Juliane Haedicke, Thomas Iftner
Sep 24, 2013·Applied Biochemistry and Biotechnology·Mahsa AlemiMandana Behbahani
Jan 28, 2014·PloS One·Dionne N DamesUNKNOWN African Caribbean Cancer Consortium
May 6, 2014·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Marina D M LimaMarina Gallottini
Oct 2, 2014·Revista brasileira de ginecologia e obstetrícia : revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia·Adriana BrunoBruno Gil de Carvalho Lima
Oct 7, 2014·Otolaryngologia polska. The Polish otolaryngology·Kamal MorshedMałgorzata Polz-Dacewicz
Oct 22, 2014·Journal of Medical Virology·Shuang LuYong Tong Cao
Nov 13, 2014·Infectious Diseases in Obstetrics and Gynecology·David H AdlerLinda-Gail Bekker
Dec 27, 2015·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Janaina CoserVagner Ricardo Lunge

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Citations

Mar 19, 2020·The Journal of Obstetrics and Gynaecology Research·Marcos P C MarquesMarco A P de Oliveira
Apr 25, 2020·Journal of Medical Virology·Brenda Evelin Barreto da SilvaLígia Mara Dolce de Lemos
Jun 17, 2020·The Pan African Medical Journal·Lucy Wanja KaraniBenuel Nyagaka
Apr 16, 2021·PloS One·Cebisile NgcamphalalaThemba G Ginindza
Aug 13, 2021·Indian Journal of Cancer·Veena G RahatgaonkarGauri A Oka

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Methods Mentioned

BETA
genotyping
biopsies
ELISA
PCR

Software Mentioned

PHRED
BLAST
Blat
CONSED
Human Genome Search
PHRAP
Basic Local Alignment System
BioEdit – Biological Sequence Alignment Editor

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