Detection and Magnetic Source Imaging of Fast Oscillations (40-160 Hz) Recorded with Magnetoencephalography in Focal Epilepsy Patients

Brain Topography
Nicolás von EllenriederEliane Kobayashi

Abstract

We present a framework to detect fast oscillations (FOs) in magnetoencephalography (MEG) and to perform magnetic source imaging (MSI) to determine the location and extent of their generators in the cortex. FOs can be of physiologic origin associated to sensory processing and memory consolidation. In epilepsy, FOs are of pathologic origin and biomarkers of the epileptogenic zone. Seventeen patients with focal epilepsy previously confirmed with identified FOs in scalp electroencephalography (EEG) were evaluated. To handle data deriving from large number of sensors (275 axial gradiometers) we used an automatic detector with high sensitivity. False positives were discarded by two human experts. MSI of the FOs was performed with the wavelet based maximum entropy on the mean method. We found FOs in 11/17 patients, in only one patient the channel with highest FO rate was not concordant with the epileptogenic region and might correspond to physiologic oscillations. MEG FOs rates were very low: 0.02-4.55 per minute. Compared to scalp EEG, detection sensitivity was lower, but the specificity higher in MEG. MSI of FOs showed concordance or partial concordance with proven generators of seizures and epileptiform activity in 10/11 patients. ...Continue Reading

References

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Citations

Apr 10, 2016·Human Brain Mapping·Giovanni PellegrinoChristophe Grova
Jul 1, 2017·Epilepsia·Birgit FrauscherJean Gotman
Mar 23, 2017·Journal of Neural Engineering·Carolina MigliorelliMiguel A Mañanas
Jul 20, 2018·Annals of Neurology·Eleonora TamiliaChristos Papadelis
Mar 12, 2019·Human Brain Mapping·Giovanni PellegrinoHartwig Roman Siebner
Feb 26, 2020·Annals of Clinical and Translational Neurology·Eleonora TamiliaChristos Papadelis
Mar 28, 2020·Journal of Neural Engineering·Carolina MigliorelliVictoria San Antonio-Arce
Feb 26, 2019·Frontiers in Neurology·Aljoscha ThomschewskiBirgit Frauscher
Oct 10, 2018·Frontiers in Human Neuroscience·Giovanni PellegrinoHartwig Roman Siebner
Nov 9, 2019·F1000Research·Christoph BaumgartnerSusanne Pirker
May 14, 2016·Journal of Neural Engineering·Andrea CancelliMarom Bikson
Aug 31, 2018·Computational Intelligence and Neuroscience·Peter HöllerYvonne Höller
Jun 18, 2017·Epilepsia·Maeike ZijlmansMichel Le Van Quyen
Nov 10, 2020·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Jeffrey R TenneyDouglas F Rose
Jan 16, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Tamir AvigdorBirgit Frauscher
Feb 12, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Stefan RamppRoland Coras
Mar 13, 2021·Annals of Neurology·Eleonora TamiliaChristos Papadelis
Apr 21, 2021·Proceedings of the National Academy of Sciences of the United States of America·Zhengxiang CaiBin He
May 5, 2021·CNS Neuroscience & Therapeutics·Li-Juan ShiJi-Cong Zhang
Nov 20, 2018·Journal of Neuroscience Methods·Gianvittorio LuriaAlberto Sorrentino
May 19, 2021·Human Brain Mapping·Giovanni PellegrinoEliane Kobayashi
Jul 21, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Elaine FoleyStefano Seri

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Software Mentioned

sLORETA
BrainVISA
Brainstorm
wMEM
OpenMEEG

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