Detection and possible prognostic relevance of p53 gene mutations in diffuse large B-cell lymphoma. An analysis of 51 cases and review of the literature

Leukemia & Lymphoma
Fábio R KerbauyJosé Kerbauy

Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma. Although the presence of p53 gene mutations has been considered as a bad prognostic feature in DLBCL, its clinical significance is still controversial. The aims of this study were: detect the presence of mutations in exons 5 to 9 of the p53 gene and correlate it to prognosis in DLBCL. Fifty-one DLBCL patients were enrolled in this study. Expression of p53 was evaluated by immunohistochemistry. The screening of p53 mutations was performed using PCR-SSCP methods. Cases showing a mobility shift on SSCP electrophoresis were analyzed by automatic sequencing. We could identify 8 missense mutations in 6 of 48 cases (12.5%). In addition, we found a known polymorphism at codon 213 and 2 instances of silent mutations. Of all mutations/polymorphisms found, 7 (64%) were localized in codons previously described as p53 hot spots in NHL cases. Of the remaining alterations (4 or 36%), 2 mutations were localized in codons previously described as hot spots for p53 in other tumors and 2 (codon 142 of the exon 5 and codon 195 of the exon 6), in codons not described as hot spots for p53 up to now. The presence of missense mutations in exons 5 to 9 of p53 gene h...Continue Reading

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Citations

Mar 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ai KotaniTasuku Honjo
Jun 10, 2006·Cell Death and Differentiation·K B SpurgersT J McDonnell
Sep 1, 2015·Critical Reviews in Oncology/hematology·Ting-Xun LuJian-Yong Li
Mar 19, 2014·PloS One·Rebeca MansoMiguel Ángel Piris
Sep 23, 2016·Journal of the Neurological Sciences·Joerg-Patrick Stübgen
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Oct 16, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Xuan J WangShaoying Li
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Aug 3, 2021·Critical Reviews in Oncology/hematology·Maria Lopez-SantillanIdoia Martin-Guerrero
Apr 7, 2009·Leukemia Research·Ronald Feitosa PinheiroMaria de Lourdes Lopes Ferrari Chauffaille

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