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Detection and quantification of mitochondrial DNA deletions in individual cells by real-time PCR

Nucleic Acids Research

Jul 24, 2002

Langping HeDouglass M Turnbull

Abstract

Defects of mitochondrial DNA (mtDNA) are an important cause of disease and play a role in the ageing process. There are multiple copies of the mitochondrial genome in a single cell. In many patients with acquired or inherited mtDNA mutations, there exists a mixture of mutated and wild t...read more

Mentioned in this Paper

Real-Time Polymerase Chain Reaction
Patterns
Genome
Luft Disease
DNA, Mitochondrial
Western Blotting
Gene Deletion
Plant fiber
Thyroid Hormone Plasma Membrane Transport Defect
Soleus Muscle Structure
139
Paper Details
References
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  • Citations150
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  • References32
  • Citations150
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Detection and quantification of mitochondrial DNA deletions in individual cells by real-time PCR

Nucleic Acids Research

Jul 24, 2002

Langping HeDouglass M Turnbull

PMID: 12136116

DOI: 10.1093/nar/gnf067

Abstract

Defects of mitochondrial DNA (mtDNA) are an important cause of disease and play a role in the ageing process. There are multiple copies of the mitochondrial genome in a single cell. In many patients with acquired or inherited mtDNA mutations, there exists a mixture of mutated and wild t...read more

Mentioned in this Paper

Real-Time Polymerase Chain Reaction
Patterns
Genome
Luft Disease
DNA, Mitochondrial
Western Blotting
Gene Deletion
Plant fiber
Thyroid Hormone Plasma Membrane Transport Defect
Soleus Muscle Structure
139

Similar Papers Found In These Feeds

Non-coding Variants in Cancer

Mutations, single nucleotide variants and large genomic rearrangements, in non-coding regions of the genome can have severe consequences such as disruption of transcription factor binding sites and functions of non-coding RNAs and can impact tumor development and progression. Here is the latest research.

Chromosomal Deletion

Chromosomal deletion includes the loss of a gene sequence of DNA. The location and the genes deleted determines the significance of this abnormality. There are many identified genetic disorders that are a result from chromosomal deletion including cri du chat and Prader-Willi syndrome. Discover the latest research on chromosomal deletions here.

Related Papers

American Journal of Human Genetics

Nature of mitochondrial DNA deletions in substantia nigra neurons

American Journal of Human GeneticsJanuary 9, 2008
Amy K ReeveDouglass M Turnbull
Paper Details
References
  • References32
  • Citations150
1234
  • References32
  • Citations150
12345...
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