Detection and quantification of sucrose as dietary biomarker using gas chromatography and liquid chromatography with mass spectrometry

Rapid Communications in Mass Spectrometry : RCM
Gunter G C KuhnleS A Bingham

Abstract

Several epidemiological studies suggest a link between the intake of refined sugars and an increased risk for colorectal, breast, pancreatic and endometrial cancer. However, other studies failed to confirm these conclusions and the reason for this may be the ambiguity of dietary assessment methods - mainly self-reporting - employed. Sucrose is an established biomarker for sugars intake, allowing the objective assessment of dietary sucrose. So far, urinary excretion of sucrose was mainly determined using an enzyme assay. However, this method is time-consuming and labour-intensive. In this study, we present a mass spectrometric method for the determination of sucrose in urine using liquid chromatography with mass spectrometry (LC/MS) which can be used for large-scale epidemiological studies.

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Citations

Aug 30, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A M C P JoosenS A Bingham
Dec 15, 2012·Nutrition Journal·Valisa E HedrickBrenda M Davy
Oct 26, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·E D'Arcy-MoskwaS L Raidal
Jul 18, 2015·Nutrients·Natasha Tasevska
Mar 20, 2015·The American Journal of Clinical Nutrition·Dianne P ReidlingerUNKNOWN Cardiovascular disease risk REduction Study (CRESSIDA) investigators
Jan 20, 2021·European Journal of Nutrition·Ines PerrarUte Alexy

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