PMID: 7528359Sep 1, 1994Paper

Detection and quantification of vascular endothelial growth factor/vascular permeability factor in brain tumor tissue and cyst fluid: the key to angiogenesis?

Neurosurgery
K WeindelH A Weich

Abstract

In primary malignant brain tumors increased vascularity and marked edema strongly suggest a possible role of the vascular endothelial growth factor/vascular permeability factor (VEGF/VPF). This was confirmed by earlier in situ hybridization studies, by analysis of the expression of the mitogen in different subsets of glioblastoma cells, and by the fact that the VEGF/VPF receptor flt-1 (fms-like tyrosine kinase) is up-regulated in tumor cells in vivo. To assess and quantify the expression of the VEGF/VPF gene and of the receptor gene, 26 surgical specimens of brain tumor tissue from 24 patients were analyzed. In most malignant gliomas, the expression level of the VEGF/VPF gene is elevated and can be increased up to 20- to 50-fold in comparison with low-grade tumors. Using polymerase chain reaction-based amplification, it could be shown that the messenger RNAs of three different VEGF/VPF forms are synthesized in tumor tissue samples. Northern blot studies revealed that in some samples a significant expression of the gene coding for placenta growth factor, a growth factor closely related to VEGF/VPF, was observed. In addition, using a radioreceptor assay it was possible to detect high VEGF/VPF-like activity in the cyst fluids of b...Continue Reading

References

Sep 30, 1992·Biochemical and Biophysical Research Communications·B I TermanP Böhlen
Mar 31, 1992·Biochemical and Biophysical Research Communications·K WeindelH A Weich
Jan 1, 1992·The Journal of Clinical Investigation·L B JakemanN Ferrara
Nov 1, 1991·Journal of Cellular Biochemistry·D T Connolly
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D MaglioneM G Persico
Feb 28, 1991·Biochemical and Biophysical Research Communications·J V OlanderJ E DeLarco
Nov 1, 1989·The Journal of Clinical Investigation·D T ConnollyJ Feder
Jun 15, 1989·Biochemical and Biophysical Research Communications·N Ferrara, W J Henzel
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D GospodarowiczJ Schilling
Aug 1, 1988·Journal of Neurosurgery·G R CriscuoloE H Oldfield
Mar 1, 1972·Annals of Surgery·J Folkman

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Citations

Jan 1, 1996·Acta neurochirurgica·A GieseM Westphal
Feb 20, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M Y SuO Nalcioglu
Aug 15, 2002·Neuropathology and Applied Neurobiology·Jesús VaqueroSantiago Oya
Apr 16, 2013·Japanese Journal of Clinical Oncology·Yoshitaka Narita
Sep 10, 2019·Cancer Medicine·Fumiyuki YamasakiKazuhiko Sugiyama
Nov 26, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M SandströmR Henriksson
Jan 1, 1997·Acta Oncologica·M LindgrenR Henriksson
Nov 25, 1998·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A Guha
Sep 1, 1996·Journal of Neuro-oncology·I E McCutcheon
Jun 18, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yue CaoTheodore S Lawrence
Jan 23, 2003·Microscopy Research and Technique·M Beatriz S Lopes
Oct 31, 2011·The Neuroradiology Journal·M Martinez GaldamezA Pérez-Higueras
Mar 22, 2015·Journal of Neuro-oncology·Lauriane GoldwirtChristine Fernandez
Dec 23, 2015·Neural Regeneration Research·Rafet ÖzayYusuf Şükrü Çağlar
Jun 24, 2017·Heart Failure Reviews·Hemalatha ThiagarajanAnbukkarasi Kaliyaperumal
Apr 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·M S Pepper
Jan 1, 1997·Acta neurochirurgica·O D Laerum
Feb 24, 2001·The Journal of Pharmacy and Pharmacology·C R Dass, T Su
Nov 1, 1995·Glia·K H Plate, W Risau
Jan 1, 1995·Breast Cancer Research and Treatment·W KolchD Marmé
Nov 30, 1999·Journal of Neurosurgery·J VaqueroC Salas
Aug 29, 2003·Neurosurgery·Mark R Harrigan
Feb 6, 2020·Cancers·Marta Obara-Michlewska, Monika Szeliga
Jun 1, 1996·Cancer Metastasis Reviews·K P Claffey, G S Robinson
Aug 1, 1997·The American Journal of Surgical Pathology·S Y LeungL P Chung
Mar 27, 2004·Neuropathology and Applied Neurobiology·S PistolesiG Fontanini

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