Detection and quantitation of immunogenic epitopes related to celiac disease in historical and modern hard red spring wheat cultivars

Food Chemistry
Maneka MalalgodaSenay Simsek

Abstract

Celiac disease (CD) develops in genetically susceptible individuals as a result of ingesting gluten-forming proteins found in cereals, such as wheat (Triticum aestivum L.), rye (Secale cereale L.) and barley (Hordeum sativum L.). There are claims that breeding practices have changed wheat protein chemistry over the years and this has resulted in modern wheat being more antigenic in terms of CD as opposed to historical wheat. The aim of this study was to detect and quantify celiac-disease-initiating peptides of α-gliadin proteins in historical and modern spring wheat cultivars. The results indicate that immunogenic epitopes are detected in both historical and modern spring wheat cultivars irrespective of release year. Quantitation indicated that the amount of immunogenic epitopes glia-α9 (PFPQPQLPY) and glia-α20 (FRPQQPYPQ), and total α-gliadin varied randomly across the cultivars that were analyzed, suggesting there is no association between cultivar release year and amounts of immunogenic epitopes and α-gliadin.

Citations

Dec 18, 2019·Foods·Maneka MalalgodaSenay Simsek
Jan 25, 2020·Journal of the Science of Food and Agriculture·Paridhi GulatiDevin J Rose
Jun 12, 2019·Foods·Iris Joye
Mar 13, 2020·Frontiers in Plant Science·Susan B AltenbachArmin Alaedini
Dec 5, 2019·Frontiers in Plant Science·Thais O AlvesMariana S L Ferreira
May 18, 2020·International Journal of Molecular Sciences·Olha LakhnekoĽudovit Škultéty
Jan 12, 2019·Nature Reviews. Disease Primers·Katri LindforsKatri Kaukinen
Dec 26, 2018·Food Chemistry·Miguel Ribeiro, Fernando M Nunes
Nov 17, 2020·Frontiers in Nutrition·Herbert WieserKatharina A Scherf
Dec 17, 2020·Nutrients·Maria Gloria MumoloMassimo Bellini
Aug 18, 2021·Comprehensive Reviews in Food Science and Food Safety·Miguel RibeiroGilberto Igrejas

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