Detection and quantitation of myocardial infarction in vivo using transmission computed tomography

Circulation
P W DohertyR W Redington

Abstract

In vivo studies were performed on 28 dogs to evaluate the usefulness of transmission computed tomography (CT) in the detection and quantitation of experimentally induced myocardial infarction. Intravenously administered contrast material was required to define the internal structure of the heart and to differentiate normal from infarcted tissue. Transmural infarcts with homogeneous central regions were visualized as areas of diminished contrast enhancement compared with the normal myocardium. All transmural infarcts of at least 24 hours' duration showed a surrounding border zone of patchy necrosis that was variable in size and had high CT numbers due to slow washout of the contrast material from this region. Infarct area determined from the images for individual slices correlated well (r = 0.976) with that calculated using pathology. The technique is very sensitive and can detect infarction within a papillary muscle. Nontransmural or patchy infarcts show up as areas of diffuse contrast enhancement without a central core of diminished enhancement. The distribution of the contrast material is similar to that of technetium-99m pyrophosphate in the border zone of the infarct in infusion studies, but in bolus studies it behaves more...Continue Reading

References

Jul 1, 1976·AJR. American Journal of Roentgenology·M M Ter-PogossianB E Sobel
Apr 1, 1979·Journal of Computer Assisted Tomography·W H BerningerE Carlsson
Feb 9, 1978·The New England Journal of Medicine·H L Abrams, B J McNeil
May 1, 1978·Radiology·S J HesselH L Abrams
May 1, 1978·Radiology·M J LiptonE Carlsson
Jan 1, 1979·The American Journal of Cardiology·C B HigginsP T Siemers
May 1, 1973·The British Journal of Radiology·J A Ambrose
Dec 1, 1973·The British Journal of Radiology·J Ambrose

❮ Previous
Next ❯

Citations

Jan 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M SaeedC B Higgins
Jan 1, 1987·International Journal of Cardiac Imaging·M J Lipton
Jan 1, 1985·International Journal of Cardiac Imaging·J S GarrettM J Lipton
Jan 1, 1987·Cardiovascular and Interventional Radiology·M J Lipton
May 1, 1985·Journal of the American College of Cardiology·R A Slutsky, W W Peck
Feb 1, 1985·Journal of the American College of Cardiology·R A Slutsky, M Murray
Sep 1, 1995·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·J R Lindner, S Kaul
Oct 24, 2009·Nature Reviews. Cardiology·Karl H SchuleriAlbert C Lardo
Sep 7, 2006·Journal of Computer Assisted Tomography·William MooreBrian Mieczkowski
Nov 25, 2000·AJR. American Journal of Roentgenology·M J LiptonZ M Hijazi
May 20, 2004·AJR. American Journal of Roentgenology·Amy GosaliaHugo Spindola-Franco
Oct 21, 2011·Radiology·Karen G Ordovas, Charles B Higgins
Apr 2, 2011·Expert Review of Cardiovascular Therapy·Andreas H Mahnken
Feb 27, 2009·Journal of Cardiovascular Computed Tomography·Dorinna D Mendoza, Wm Guy Weigold
Jun 7, 2006·Journal of Magnetic Resonance Imaging : JMRI·Erik HedströmTomas Bjerner
Mar 1, 1987·IEEE Transactions on Bio-medical Engineering·J J McInerneyM D Herr
Mar 1, 1988·Progress in Cardiovascular Diseases·F R Cobb, A Chu
Mar 1, 1986·Progress in Cardiovascular Diseases·M J LiptonD P Boyd
Nov 1, 1983·Clinical Radiology·S J BarterA Maseri
Jan 15, 2004·Cardiology Clinics·Lawrence M BoxtMelvin E Clouse
Jan 1, 1982·The American Journal of Cardiology·C G SkiöldebrandT T Hayashi
Sep 19, 2009·JACC. Cardiovascular Imaging·Pim J de Feyter, Koen Nieman
Sep 1, 1984·American Heart Journal·M Osbakken, R W Briggs
Jan 1, 1983·Acta Radiologica: Diagnosis·H G RingertzE Carlsson
Jan 1, 1985·Acta Radiologica: Diagnosis·D A FeinbergE Carlsson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.