In vivo studies were performed on 28 dogs to evaluate the usefulness of transmission computed tomography (CT) in the detection and quantitation of experimentally induced myocardial infarction. Intravenously administered contrast material was required to define the internal structure of the heart and to differentiate normal from infarcted tissue. Transmural infarcts with homogeneous central regions were visualized as areas of diminished contrast enhancement compared with the normal myocardium. All transmural infarcts of at least 24 hours' duration showed a surrounding border zone of patchy necrosis that was variable in size and had high CT numbers due to slow washout of the contrast material from this region. Infarct area determined from the images for individual slices correlated well (r = 0.976) with that calculated using pathology. The technique is very sensitive and can detect infarction within a papillary muscle. Nontransmural or patchy infarcts show up as areas of diffuse contrast enhancement without a central core of diminished enhancement. The distribution of the contrast material is similar to that of technetium-99m pyrophosphate in the border zone of the infarct in infusion studies, but in bolus studies it behaves more...Continue Reading
Pathophysiology of technetium-99m stannous pyrophosphate and thallium-201 scintigraphy of acute anterior myocardial infarcts in dogs
Regional myocardial perfusion assessed with N-13 labeled ammonia and positron emission computerized axial tomography
Detection of edema associated with myocardial ischemia by computerized tomography in isolated, arrested canine hearts
An extravascular component of contrast enhancement in cranial computed tomography. Part II. Contrast enhancement and the blood-tissue barrier
Pathophysiology of cardiogenic shock. Quantification of myocardial necrosis, clinical, pathologic and electrocardiographic correlations
Reperfused myocardial infarctions on T1- and susceptibility-enhanced MRI: evidence for loss of compartmentalization of contrast media
ECG-gated multi-detector row spiral CT in the assessment of myocardial infarction: correlation with non-invasive angiographic findings
Dual-energy CT of the heart for diagnosing coronary artery stenosis and myocardial ischemia-initial experience.
Exercise thallium-201 single photon emission computed tomography for the diagnosis of coronary artery disease: what should we expect from SPECT?
Effects of transient coronary ischemia and reperfusion on myocardial edema formation and in vitro magnetic relaxation times
Myocardial infarct size determined by computed transmission tomography in canine infarcts of various ages and in the presence of coronary reperfusion
Effects of beta-adrenergic blockade on the natural progression of myocardial infarct size and compensatory hypertrophy
Computed tomographic analysis of the effects of hyperosmolar mannitol and methylprednisolone on myocardial infarct size
Insights into the assessment of myocardial perfusion offered by different cardiac imaging modalities
Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar
Is functional improvement after myocardial infarction predicted with myocardial enhancement patterns at multidetector CT?
Impact of tube current in the quantitative assessment of acute reperfused myocardial infarction with 64-slice delayed-enhancement CT: a porcine model
Impact of contrast material volume on quantitative assessment of reperfused acute myocardial infarction using delayed-enhancement 64-slice CT: experience in a porcine model.
In vivo evaluation of myocardial infarction by computed tomography: an experiment with electrocardiographic gating
Importance of perfusion in myocardial viability studies using delayed contrast-enhanced magnetic resonance imaging
In vivo assessment of left ventricular wall and chamber dynamics during transient myocardial ischemia using cine computed tomography
Comparison of thallium-201 SPECT and planar imaging methods for quantification of experimental myocardial infarct size
Imaging of acute myocardial infarction in man with contrast-enhanced computed transmission tomography
Detection of healed myocardial infarction with multidetector-row computed tomography and comparison with cardiac magnetic resonance delayed hyperenhancement
Noninvasive quantification of jeopardized myocardial mass in dogs using 2-dimensional echocardiography and thallium-201 tomography
In vivo assessment by computed tomography of the natural progression of infarct size, left ventricular muscle mass and function after acute myocardial infarction in the dog
Contrast enhanced and functional magnetic resonance imaging for the detection of viable myocardium after infarction
ECG synchronized computed tomography in clinical evaluation of total and regional cardiac motion: comparison of postmyocardial infarction to normal hearts by rapid sequential imaging
Use of computerized tomography to assess myocardial infarct size and ventricular function in dogs during acute coronary occlusion and reperfusion
Diagnosis of myocardial ischemia combining multiphase postmortem CT-angiography, histology, and postmortem biochemistry
Attenuation changes of the normal and ischemic canine kidney. Dynamic CT scanning after intravenous contrast medium bolus
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