Detection and replication of linkage to a complex human disease

Genetic Epidemiology
S O Moldin

Abstract

Efforts to map susceptibility loci for complex human diseases frequently result in weak evidence for linkage, followed by failures to convincingly replicate. If a disease locus influences both affection status (AF) and a quantitative trait, a variant of the extreme discordant sib pair (EDSP) strategy may be used to judiciously sample families for a replication study. This approach was evaluated by conducting joint segregation and linkage analysis of four bivariate phenotypes, each comprising AF and one quantitative trait (Q2, Q3, Q4, Q5), and undertaking a genomic scan of the GAW10 Problem 2B data set. Suggestive evidence was found for linkage of AF/Q2 to marker D8G26 (lod = 1.63, chi 2 = 7.52, p = 3.05 x 10(-3)). Sets of 23 EDSP families were selected based on Q2 values that demarcated the bottom 1%, 2%, 5%, 10%, or 20% of the distribution. Highly significant evidence for linkage was found when the 1% or 2% cutoffs were used (lod > 4, chi 2 > 20, p < 4 x 10(-6)), but more than 1,000 families had to be screened. Significant evidence for linkage (lod = 3.24, chi 2 = 14.91, p = 5.63 x 10(-5)) was found in the EDSP sample obtained using a 5% cutoff: about 300 families had to be screened. Only suggestive evidence for linkage (lod =...Continue Reading

References

Jan 1, 1995·Genetic Epidemiology·S O Moldin, P Van Eerdewegh
Sep 13, 1996·Science·N Risch, K Merikangas

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Citations

Nov 13, 2004·Current Psychiatry Reports·Kathleen Ries Merikangas, Nancy C P Low
Sep 22, 2001·Biological Psychiatry·G WintererD R Weinberger
Oct 4, 2002·Biological Psychiatry·Kathleen R MerikangasJoseph S Takahashi
Aug 10, 2000·Proceedings of the National Academy of Sciences of the United States of America·J Hoh, J Ott
Apr 19, 2008·European Journal of Pharmacology·Annetrude J G de Mooij-van MalsenMartien J H Kas

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