Detection and replication of QTL underlying resistance to gastrointestinal nematodes in adult sheep using the ovine 50K SNP array

Genetics, Selection, Evolution : GSE
Marina AtlijaB Gutiérrez-Gil

Abstract

Persistence of gastrointestinal nematode (GIN) infection and the related control methods have major impacts on the sheep industry worldwide. Based on the information generated with the Illumina OvineSNP50 BeadChip (50 K chip), this study aims at confirming quantitative trait loci (QTL) that were previously identified by microsatellite-based genome scans and identifying new QTL and allelic variants that are associated with indicator traits of parasite resistance in adult sheep. We used a commercial half-sib population of 518 Spanish Churra ewes with available data for fecal egg counts (FEC) and serum levels of immunoglobulin A (IgA) to perform different genome scan QTL mapping analyses based on classical linkage analysis (LA), a combined linkage disequilibrium and linkage analysis (LDLA) and a genome-wide association study (GWAS). For the FEC and IgA traits, we detected a total of three 5 % chromosome-wise significant QTL by LA and 63 significant regions by LDLA, of which 13 reached the 5 % genome-wise significance level. The GWAS also revealed 10 significant SNPs associated with IgAt, although no significant associations were found for LFEC. Some of the significant QTL for LFEC that were detected by LA and LDLA on OAR6 overlapp...Continue Reading

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Citations

Jan 1, 2017·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Weizhen LiuMichael Pumphrey
Feb 12, 2017·Genetics, Selection, Evolution : GSE·Eyal SeroussiElisha Gootwine
Sep 8, 2017·Journal of Animal Science and Biotechnology·Mariana Piatto BertonJosé Bento Sterman Ferraz
Sep 15, 2017·Ecology and Evolution·Scott L NuismerMark F Dybdahl
Jul 6, 2017·Genetics, Selection, Evolution : GSE·Serap GonenJohn M Hickey
Sep 6, 2020·Genetics, Selection, Evolution : GSE·Seyed Mohammad GhoreishifarArash Javanmard
Mar 8, 2020·Animals : an Open Access Journal From MDPI·Wilber Hernández-MontielRoberto Zamora-Bustillos
May 19, 2017·IET Systems Biology·Dong-Hyuk KimAh-Ram Kim
May 1, 2021·Animals : an Open Access Journal From MDPI·Michael N RomanovDarren K Griffin
Aug 6, 2021·Frontiers in Genetics·Adam AbiedJoram M Mwacharo

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Methods Mentioned

BETA
chip
ELISA
genotyping

Software Mentioned

Oar
LDLA
R
Ensembl
GenCall
lsmeans
QTLMap
BioMart
VerifTyp
DMU

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