PMID: 6363623Jan 1, 1984Paper

Detection by ELISA of IgA and IgM antibodies in secretion and IgM antibodies in serum in primary lower respiratory syncytial virus infection

Journal of Medical Virology
A HornslethP A Krasilnikof

Abstract

Twenty-six infants and children with primary lower RS virus infection, diagnosed by the detection of RS virus in nasopharyngeal secretion (NPS) by use of immunofluorescent antibody (FA) technique, were studied with respect to the presence of IgA and IgM antibodies. Samples of NPS and serum obtained during the first 3-4 months following the beginning of illness, were investigated. Employing a reverse ELISA technique, we found IgM antibodies in the acute, but not during the convalescent, phase of illness in NPS from 20 of the patients and in serum from 21 of the patients. The majority of the IgM antibody conversions observed occurred in NPS as well as in serum on days 5-8 following the illness. RS virus IgA antibodies, also detected by a reverse ELISA technique, were demonstrated in NPS in 22 of the patients, with antibody conversions being found in 19 of the patients on days 5-8 following the beginning of the illness. Two patients still had IgA antibodies in NPS approximately 3 months FSOI. By comparison, RS virus was detected in acute-phase NPS by double-antibody sandwich ELISA in 25 of the 26 patients investigated.

References

Jul 1, 1978·The Journal of Infectious Diseases·K McIntoshR M Barkin
Jan 1, 1982·Journal of Medical Virology·J T van der LogtJ van der Veen
Jul 1, 1981·The Journal of Allergy and Clinical Immunology·K P Mathews
Aug 1, 1981·The Journal of Pediatrics·M FishautP L Ogra

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Citations

Nov 1, 1984·Archives of Disease in Childhood·B FriisP Uldall
Apr 1, 1993·Archives of Disease in Childhood·X T KongD R Brewster
Dec 1, 1986·The Journal of Hygiene·R CeveniniV Sambri

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