Detection of 3,3'-Dichlorobiphenyl in Human Maternal Plasma and Its Effects on Axonal and Dendritic Growth in Primary Rat Neurons

Toxicological Sciences : an Official Journal of the Society of Toxicology
Sunjay SethiPamela J Lein

Abstract

3,3'-Dichlorobiphenyl (PCB 11), a byproduct of pigment production, is increasingly detected in environmental samples. While more highly chlorinated PCB congeners are known developmental neurotoxicants, nothing is known about the potential developmental neurotoxicity of PCB 11. To address this critical data gap, we measured PCB 11 levels in human maternal plasma and quantified the effects of PCB 11 and its major metabolites on morphometric parameters of neuronal connectivity in cultured primary neurons. Mass spectrometry analyses of plasma from 241 pregnant women enrolled in the MARBLES study (University of California, Davis) detected PCB 11 in all samples at concentrations ranging from 0.005 to 1.717 ng/ml. Morphometric analyses of primary neuron-glia co-cultures dissociated from the neocortices or hippocampi of neonatal Sprague Dawley rats exposed to vehicle or concentrations ranging from 1 attamolar (aM) to 1 micromolar (µM) of PCB 11, OH-PCB 11, or PCB 11 sulfate indicated that PCB 11 and both metabolites significantly increased axonal and dendritic growth in cortical and hippocampal pyramidal neurons. PCB 11 significantly altered neuronal morphogenesis at concentrations as low as 1 femtomolar (fM), which is ∼0.22 ng/ml. The...Continue Reading

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Citations

Nov 6, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kimberly P KeilPamela J Lein
Nov 13, 2019·Environmental Science and Pollution Research International·Carolyn KlockePamela J Lein
Feb 9, 2020·International Journal of Molecular Sciences·Carolyn Klocke, Pamela J Lein
Jul 24, 2020·Environmental Health Perspectives·Fabian A GrimmIvan Rusyn
Jul 31, 2019·Environmental Science and Pollution Research International·Panithi SaktrakulklaKeri C Hornbuckle
Jun 24, 2018·Nanomaterials·Alexander E HampeErkin Seker
Jan 29, 2019·Neural Regeneration Research·Mariano Bisbal, Mónica Sanchez
Jan 9, 2019·Frontiers in Neuroscience·Marta d'Amora, Silvia Giordani
Jul 27, 2017·Environmental Science and Pollution Research International·Kiran DhakalLarry W Robertson
Sep 23, 2020·Toxics·Harmanpreet Kaur PanesarPamela J Lein
Mar 19, 2021·Chemical Research in Toxicology·Chun-Yun ZhangHans-Joachim Lehmler
Aug 3, 2021·Current Research in Toxicology·Kimberly P Keil StietzPamela J Lein
Oct 17, 2020·Environmental Science & Technology·Chun-Yun ZhangHans-Joachim Lehmler

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