Detection of a large spectrum of viral infections in conjunctival premalignant and malignant lesions.

International Journal of Cancer. Journal International Du Cancer
Luisa GalatiMassimo Tommasino

Abstract

To study the interaction between HIV and other carcinogenic infections in conjunctival squamous cell carcinoma (SCC), we evaluated the presence of a broad spectrum of human viruses in conjunctiva specimens. Beta Human papillomavirus (HPV; n = 46), gamma HPV (n = 52), polyomaviruses (n = 12) and herpes viruses (n = 3) was determined in DNA extracted from 67 neoplastic and 55 non-neoplastic conjunctival tissues of HIV-positive and HIV negative subjects by Luminex-based assays. Next-generation sequencing (NGS) was also used to further characterize the presence of cutaneous HPVs. Detection of beta-2 HPV infections was associated with the risk of neoplasia (adjusted odds ratio [aOR] 3.0; 95% confidence interval [CI] 1.3-6.8), regardless of HIV status (HIV positive, aOR 2.6, 95% CI 0.9-7.7; HIV negative, aOR 3.5, 95% CI 0.9-14.4). EBV was strongly associated with the risk of neoplasia (aOR 12.0, 95% CI 4.3-33.5; P < .01) mainly in HIV individuals (HIV positive, aOR 57.5; 95% CI: 10.1-327.1; HIV negative aOR 2.6; 95% CI: 0.2-34.7). NGS allowed to identify 13 putative novel HPVs in cases and controls. Our findings suggest a role of beta HPV types and EBV, in conjunctival SCC. However, additional studies of viral expression in tumor tis...Continue Reading

References

May 1, 1995·Survey of Ophthalmology·G A Lee, L W Hirst
Jun 1, 1996·The British Journal of Ophthalmology·P Courtright
Nov 1, 1996·British Journal of Cancer·R Newton
Mar 5, 2002·Ophthalmology·Ingrid U ScottGerard J Nuovo
Aug 15, 2002·British Journal of Cancer·R NewtonUNKNOWN Uganda Kaposi's Sarcoma Study Group
Jan 13, 2006·British Journal of Cancer·M L TorneselloF M Buonaguro
Feb 4, 2006·Journal of Clinical Microbiology·Markus SchmittTim Waterboer
Aug 19, 2007·Journal of the National Cancer Institute·Claire M VajdicAndrew E Grulich
Aug 19, 2007·The Journal of Infectious Diseases·Ola ForslundUNKNOWN Viraskin Study Group
Apr 8, 2009·The Lancet Oncology·Véronique BouvardUNKNOWN WHO International Agency for Research on Cancer Monograph Working Group
Dec 10, 2009·British Journal of Cancer·C Ateenyi-AgabaE Weiderpass
Mar 30, 2010·Infectious Agents and Cancer·Kenneth O SimbiriErle S Robertson
May 24, 2011·Experimental and Molecular Pathology·Gulfaraz KhanSayel Daoud
Oct 22, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Dana E RollisonMichael Pawlita
Nov 22, 2011·Infectious Agents and Cancer·Raúl PeraltaMauricio Salcedo
Mar 16, 2012·American Journal of Epidemiology·Kristin AnderssonJoakim Dillner
Mar 29, 2013·International Journal of Cancer. Journal International Du Cancer·Shohreh F FarzanMargaret R Karagas
Nov 19, 2013·Tropical Medicine & International Health : TM & IH·Stephen GichuhiMatthew J Burton
Sep 18, 2015·JAMA Ophthalmology·Stephen GichuhiMatthew J Burton
May 10, 2017·Open Forum Infectious Diseases·Anna-Barbara MoscickiMassimo Tommasino
May 27, 2017·The Journal of Infectious Diseases·Shalaka S HamprasMassimo Tommasino
Oct 13, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jan N Bouwes BavinckUNKNOWN EPI-HPV-UV-CA group
Mar 23, 2018·Journal of Translational Medicine·Noemy StaritaMaria Lina Tornesello
Sep 6, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Heather GriffinJohn Doorbar

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Citations

Jul 17, 2020·MSphere·Lucia MinoniMassimo Tommasino
Dec 19, 2020·Current Opinion in Infectious Diseases·Mazvita MuchengetiTafadzwa G Dhokotera
Oct 11, 2020·Cancer Treatment and Research Communications·Alex MremiJohn Bartlett

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