Oct 1, 1977

Detection of a new lipoprotein: Lp(a). Its occurrence in atherosclerosis with or without hyperlipemia

Annales de médecine interne
J JaillardJ C Fruchart

Abstract

Detected using a method involving gradient electrophoresis on polyacrylamide gel, the presence of a high level of an Lp(a) was demonstrated in 17% of control subjects and 39% oh hyperlipidaemic subjects explored. The difference appeared to be particularly significant in subjects with a pure hypercholesterolaemia (type IIA) or dominant hypercholesterolaemia (type IIB), which may be accounted for by the antigenic communities and related substances in the lipid composition uniting Lp(a) to LDL. The association of frank atherosclerosis with the hyperlipidaemia substantially increased the frequency of high levels of circulating Lp(a). A combined elevation of levels of Lp(a) and LDL would seem to be associated with a particular atherogenic power.

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Mentioned in this Paper

SDS-PAGE
Antigenic Specificity
LDL-1
Hypercholesterolemia
Hyperlipidemia
Atherosclerosis
Lipoproteins
Arteriosclerosis
Lipidemias
Lipids

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